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Azelaic acid is a drug for the prevention and treatment of skin diseases, mainly used for the treatment of acne, melasma and skin melanin deposition.Widely used in medicine and cosmetics.
Name | Azelaic acid |
CAS No. | 123-99-9 |
Other Names | Nonanedioic acid |
MF | C9H16O4 |
EINECS No. | 204-669-1 |
Grade | cosmetic grade |
Purity | 98% |
Appearance | White to slightly yellow crystalline powder |
Application | Cosmetic raw material |
melting point: | 98 °C |
boiling point: | 286 °C100 mm Hg(lit.) |
Density: | 1,029 g/cm3 |
flash point: | 215 °C |
density(g/mL,25/4℃): | (d110.6/4)1.225 |
1.Azelaic acid can reduce the free fatty acids and lipids on the skin surface, showing anti-keratinization effect on the skin of normal people or acne patients.
2.Azelaic acid can inhibit or kill anaerobic and aerobic bacteria in the skin area.
3.Azelaic acid can reduce skin melanin production in patients with age spots.
4.Azelaic acid also has anti-proliferative and anti-cytotoxic effects.
Azelaic acid is a drug for the prevention and treatment of skin diseases, mainly used for the treatment of acne, melasma and skin melanin deposition.Widely used in medicine and cosmetics.
Name | Azelaic acid |
CAS No. | 123-99-9 |
Other Names | Nonanedioic acid |
MF | C9H16O4 |
EINECS No. | 204-669-1 |
Grade | cosmetic grade |
Purity | 98% |
Appearance | White to slightly yellow crystalline powder |
Application | Cosmetic raw material |
melting point: | 98 °C |
boiling point: | 286 °C100 mm Hg(lit.) |
Density: | 1,029 g/cm3 |
flash point: | 215 °C |
density(g/mL,25/4℃): | (d110.6/4)1.225 |
1.Azelaic acid can reduce the free fatty acids and lipids on the skin surface, showing anti-keratinization effect on the skin of normal people or acne patients.
2.Azelaic acid can inhibit or kill anaerobic and aerobic bacteria in the skin area.
3.Azelaic acid can reduce skin melanin production in patients with age spots.
4.Azelaic acid also has anti-proliferative and anti-cytotoxic effects.
Analysis | Specification | Result | Test Method |
Physical Description | |||
Appearance | White or off white powder
| White powder | Visual |
Odor | Typical | Typical | Organoleptic |
Taste | Typical | Typical | Olfactory |
Loss on drying | 1.0% Max | 0.28% | 5g/105℃/2hrs |
Residue on ignition | 0.1% Max | 0.08% | 2g/525℃/3hrs |
Chemical Tests | |||
Azelaic acid | 98% Min | 99.25% | GC |
Heavy metals | 10.0ppm Max | <10.0ppm | ICP/MS |
Aesenic (As) | 1.0ppm Max | <1.0ppm | ICP/MS |
Lead (Pb) | 1.0ppm Max | <1.0ppm | ICP/MS |
Mercury (Hg) | 1.0ppm Max | <1.0ppm | ICP/MS |
Microbiology control | |||
Total plate Count | 1000cfu/g Max | <1000cfu/g | USP |
Yeast & Mold | 100cfu/g Max | <100cfu/g | USP |
E.coli | Negative | Negative | AOAC |
Salmonella | Negative | Negative | USP |
Staphylococcus aureus | Negative |
| USP |
Conclusion | Complies with the in-house standards. | ||
General Status | Non-GMO, ISO Certificated. | ||
Packing and Storage | |||
Packing: Pack in paper-carton and two plastic-bags inside. | |||
Shelf life: 2 year when properly stored. | |||
Storage: Store in a well-closed place with constant low temperature and no direct sun light. |
Analysis | Specification | Result | Test Method |
Physical Description | |||
Appearance | White or off white powder
| White powder | Visual |
Odor | Typical | Typical | Organoleptic |
Taste | Typical | Typical | Olfactory |
Loss on drying | 1.0% Max | 0.28% | 5g/105℃/2hrs |
Residue on ignition | 0.1% Max | 0.08% | 2g/525℃/3hrs |
Chemical Tests | |||
Azelaic acid | 98% Min | 99.25% | GC |
Heavy metals | 10.0ppm Max | <10.0ppm | ICP/MS |
Aesenic (As) | 1.0ppm Max | <1.0ppm | ICP/MS |
Lead (Pb) | 1.0ppm Max | <1.0ppm | ICP/MS |
Mercury (Hg) | 1.0ppm Max | <1.0ppm | ICP/MS |
Microbiology control | |||
Total plate Count | 1000cfu/g Max | <1000cfu/g | USP |
Yeast & Mold | 100cfu/g Max | <100cfu/g | USP |
E.coli | Negative | Negative | AOAC |
Salmonella | Negative | Negative | USP |
Staphylococcus aureus | Negative |
| USP |
Conclusion | Complies with the in-house standards. | ||
General Status | Non-GMO, ISO Certificated. | ||
Packing and Storage | |||
Packing: Pack in paper-carton and two plastic-bags inside. | |||
Shelf life: 2 year when properly stored. | |||
Storage: Store in a well-closed place with constant low temperature and no direct sun light. |