Ornithine Powder

 

Ornithine powder is a non-protein amino acid that does not directly participate in protein synthesis. Its chemical formula is C₅H₁₂N₂O₂, and it is a core intermediate metabolite of the urea cycle.

 

Its molecular structure contains an α-amino group and a side chain amino group, which makes it play a key role in nitrogen metabolism.

 

Source:

 

• Natural food: Red meat, fish, dairy products and beans have high content, but the daily intake in the normal diet is only about 0.5-2 grams.

 

• Supplement form: Capsules or powders, the recommended dose is usually 2-6 grams/day, it is often combined with arginine and citrulline to enhance absorption.

 

 

Analysis	Specification	Result
Physical Description
Assay	99%~101%	99.5%
Appearance	White powder	White powder
Loss on Drying	0.2% Max	0.07%
pH	5.0 - 6.0	5.8
Residue on Ignition	0.1% Max	0.06%
Specific Rotation	+23°~+25°	+23.64°
Sulphate (SO4)	0.02% Max	<0.02%
Organic volatile impurities	Meet the requirements	Meet the requirements
Iron (Fe)	10.0ppm Max	<10.0ppm
Ammonlum	0.02% Max	<0.02%
Heavy Metals	10.0ppm Max	<10.0ppm
Arsenic	1.0ppm Max	<1.0ppm
Conclusion	Complies with the standards.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Urea cycle
Ornithine reacts with ammonia and carbon dioxide to generate citrulline, which is eventually converted into urea and excreted from the body. It is the core mechanism for the liver to detoxify ammonia.

 

2. Precursor of polyamine synthesis
Ornithine powder generates putrescine through decarboxylation, and further synthesizes spermine and spermidine, regulating cell proliferation, differentiation and DNA stability.

 

3. Energy metabolism
It can participate in the generation of glutamate and proline, indirectly supporting the tricarboxylic acid cycle and collagen synthesis.

 

 

1. Clinical medicine:

• Used in the treatment of hepatic encephalopathy, such as intravenous injection of ornithine aspartate.
• Assisted in the repair of burns and traumatic tissues (promoting growth hormone secretion).

 

2. Sports nutrition:

• Combined with arginine to increase growth hormone levels and enhance muscle recovery, ornithine powder can reduce fatigue after exercise.
• Ornithine α-ketoglutarate is used as a supplement to inhibit muscle catabolism.

 

3. Anti-aging:
The latest research has found that its derivative putrescine may delay cell aging through the autophagy pathway.

 

 

1. Metabolic complementarity

• Ornithine: As an intermediate in the urea cycle, it promotes ammonia detoxification and reduces fatigue after exercise; it supports cell repair by generating polyamines through decarboxylation.

 

• Arginine: As a precursor of nitric oxide (NO), it improves blood flow and oxygen transport; it is directly involved in the regulation of protein synthesis and growth hormone (GH) secretion.

 

• Synergy point: Ornithine powder reduces blood ammonia levels through the urea cycle and relieves arginine metabolic pressure, while arginine provides a nitrogen source for ornithine regeneration, forming a metabolic closed loop.

 

2. Enhanced secretion of growth hormone (GH)

Both stimulate the pituitary gland to release GH through different pathways:

 

• Arginine directly activates the hypothalamus-pituitary axis;
• Ornithine may inhibit somatostatin.

 

 

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