Pyroglutamic Acid Powder

 

Pyroglutamic acid powder, also known as 5-oxoproline, is a non-standard amino acid and a cyclized derivative of glutamic acid. It plays many important roles in biochemistry and medicine.

 

1. Physical properties:

It is a white crystalline powder, easily soluble in water, and has two main isomers, L-type and D-type, with L-type being the main isomer in the body.

 

2. Stability:

It is easily decomposed under high temperature or strong acidic conditions, but is relatively stable under neutral pH conditions.

 

3. Synthesis pathway:

• Glutamate cyclization: Glutamate is generated by dehydration under enzymatic or non-enzymatic conditions.
• Glutathione metabolism: Pyroglutamic acid powder can be generated during glutathione degradation.

4. Metabolic destination:

It is hydrolyzed into glutamate by Pyrrolidonyl Peptidase and re-enters the amino acid metabolism pool.

 

 

Item	Specification	Result	Test Methods
Appearance	white powder	Conforms	Organoleptic
Odor & taste	Characteristic	Conforms	Organoleptic
Mesh size	Through 80 mesh	Conforms	80 mesh screen
Assay	≥98.0%	99.23%(HPLC)	HPLC
Loss on Drying	≤5.00%	0.35	Drying Method
Ash	≤5.00%	0.49	Ashing Method
Heavy metals
Total Heavy Metals	≤10ppm	Conforms
Arsenic	≤1ppm	Conforms	GF AAS
Lead	≤2ppm	Conforms	AFS
Cadmium	≤1ppm	Conforms	AFS
Hygrargyrum	≤0.1ppm	Conforms	AFS
Residual Solvent	Meet the requirements	Conforms	SOP/SA/SOP/SUM/304
Pesticide Residue	Meet the requirements	Not detected	SOP/SA/SOP/SUM/304
Microbiological Tests
Total Plate Count	≤5000cfu/g	Conforms	Bacterial culture
Total Yeast & Mold	≤100cfu/g	Conforms	Bacterial culture
E.Coli	Negative	Conforms	Bacterial culture
Salmonella	Negative	Conforms	Bacterial culture
Staphylococcus	Negative	Conforms	Bacterial culture

 

 

1. Neuroprotective effect:
As a neurotransmitter regulator, it may affect cognitive function. It can also participate in the glutamine cycle in the brain and maintain neuronal energy supply.

 

2. Medical application:

• Diagnostic marker: abnormally elevated levels in urine in certain metabolic diseases.
• Drug carrier: used to improve the ability of drugs to penetrate the blood-brain barrier.

 

3. Cosmetic field:
It can be used as a moisturizing ingredient and added to cosmetics.

 

(1) Composition of natural moisturizing factor

 

• Moisturizing

Pyroglutamic acid powder is one of the key ingredients of the skin's natural moisturizing factor. It can combine with water molecules in the stratum corneum to enhance the skin's moisturizing ability and relieve dryness and desquamation. It is often used in cosmetics with hyaluronic acid, ceramide and other ingredients to enhance moisturizing effects.

 

• Comparative advantages

Compared with traditional moisturizers (such as glycerin), it has a smaller molecular weight and stronger permeability. It can quickly replenish deep moisture and has a lower stickiness.

 

(2) Promote skin barrier repair

 

• Enhance keratinocyte metabolism

By regulating the glutamine metabolic pathway, it accelerates the renewal of stratum corneum cells and helps repair damaged barriers.

 

• Anti-inflammatory and soothing

Pyroglutamic acid powder can inhibit the release of inflammatory factors and relieve redness and stinging caused by damaged barriers. It is suitable for auxiliary care of rosacea or atopic dermatitis.

 

(3) Anti-aging and anti-oxidation

 

• Scavenging free radicals

As an intermediate in glutathione (GSH) metabolism, it indirectly enhances the skin's antioxidant capacity and neutralizes free radicals caused by ultraviolet (UV) and pollution.

 

• Stimulating collagen synthesis

It can improve fine lines and sagging by activating fibroblasts and promoting the production of type I collagen.

 

 

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