Urolithin B Powder

 

Urolithin B powder(Uro B) is a natural compound produced by intestinal bacteria from the ingestion of ellagitannins (ET) and ellagic acid (EA), which is found in pomegranate and raspberries. Rich in complex polyphenols in foods such as , blueberries and chestnuts.

 

Studies have found that Uro B has powerful antioxidant and anti-inflammatory properties that prevent the development of hyperlipidemia, cardiovascular disease (CVD), and tumors.

 

 

Item	Specification	Test Method
Appearance	White to Off-white Powder	Internal
Urolithin A	≥98%	HPLC
Condition	No offensive taste and smell	Internal
Heavy Metals(Pb),ppm	≤10	GB 5009.74
Arsenic,ppm	≤1	GB 5009.11
Lead,ppm	≤1	GB 5009.12
Mercury,ppm	≤0.3	GB 5009.17
Cadmium,ppm	≤0.3	GB 5009.15
Colonies Number, CFU/g	≤1000	GB 4789.2
Yeasts & Molds, CFU/g	≤50	GB 4789.15
Salmonella SP.	0/25g	GB 4789.4
Staphylococcus	0/25g	GB 4789.10
E. Coli, MPN/g	0/25g	GB 4789.3

 

 

1. Regulation of steroid metabolism

Urolithin B powder blocks the conversion pathway of androstenedione to estrone by competitively inhibiting aromatase (CYP19A1, Ki=0.85μM). Preclinical studies have shown:

 

• Increases IGF-1 receptor density in skeletal muscle cells by 37%.
• Combined supplementation can increase type II muscle fiber cross-sectional area by 12.6% in resistance trainees.

 

2. Reconstruction of redox homeostasis
As the end product of intestinal metabolism of ellagic acid, the benzofuranone group in its molecular structure has:

 

• Superoxide dismutase (SOD) mimic activity (scavenging efficiency reaches 82% of natural enzyme).
• Activating the Nrf2/ARE pathway increases the expression of heme oxygenase-1 (HO-1) by 5 times.
• Clinically proven, urolithin B powder can penetrate the blood-brain barrier (cerebrospinal fluid concentration reaches 23% of plasma) and reduce β-amyloid plaque deposition in AD model mice by 41%.

 

3. Cardiovascular Protection Network

 

• Cholesterol reverse transport: Promote ABCA1-mediated HDL production (53% reduction in atherosclerotic plaque area in mouse model).
• Endothelial repair: Activating eNOS increases NO production by 2.1 times and reduces systolic blood pressure by an average of 9.2mmHg.
• Inhibits the expression of MMP-9 in vascular smooth muscle cells and delays the process of vascular calcification.

 

 

4. Inflammation-mitochondria axis regulation

 

NF-κB inhibition: Blocks IκBα phosphorylation and reduces TNF-α secretion by 68%.

Activation of mitophagy: Upregulates the PINK1/Parkin pathway and improves muscle cell ATP production efficiency.

Human trials have shown that urolithin B powder can increase maximum oxygen uptake.

 

5. Neuroprotective effect

 

• Regulation of tau protein: inhibits GSK-3β activity (IC50=3.2μM), reduces hyperphosphorylation, and improves the cognitive score of Alzheimer's disease model by 34%.
• Neurotransmitter balance: Up-regulates the expression of brain-derived neurotrophic factor (BDNF), increasing hippocampal neurogenesis rate by 22%.
• Preclinical data show antidepressant efficacy comparable to fluoxetine.

 

6. Anti-aging

 

• Telomere protection: inhibits TERC RNA degradation and prolongs the rate of telomere loss.
• SASP inhibition: Urolithin B powder reduces secreted phenotypic factors associated with aging by 42-67%.
• The amount of collagen I synthesized in skin fibroblasts increases by 89%.

 

 

Fruiterco can provide efficient and convenient delivery methods for the products that customers need. For example: air, sea, express, you can rest assured of product quality problems during transportation.

 

We have professional business staff to communicate with you about your product needs and understanding. There is a professional mailbox system, you can leave a message at any time, we will reply as soon as we see it. If you have any product needs, you can leave a message at any time and we will reply as soon as we see it. Contact us for more details: Email: info@fruiterco.com.

 

 

 

Our products have obtained Organic, Halal, Kosher, HACCP, and USDA certifications. The company has also successfully passed ISO 22000 certification for food safety management systems. We are committed to providing our customers with high-quality products and support independent re-testing to ensure product quality.

 

 

 

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