Imperatorin: Source、Benefits And Uses

 

Imperatorin powder is a natural furanocoumarin compound widely distributed in various plants, especially abundant in plants of the Apiaceae family.
It has poor solubility, being insoluble in water but readily soluble in organic solvents.

 

It is mainly found in plants such as Angelica dahurica, Saposhnikovia divaricata, Notopterygium incisum, Glehnia littoralis, Peucedanum ostruthium, Atalantia missionis, and Flacourtia jangomas.

 

 

1. Anti-inflammatory
It can inhibit the release of inflammatory factors, reduce oxidative stress damage, and protect cells from free radical damage.

 

2. Anti-tumor
It can inhibit cancer cell proliferation and induce apoptosis in tumor cells.

 

3. Neuroprotection
Imperatorin improves learning and memory impairment in Alzheimer's disease models and inhibits neuroinflammation.

 

4. Improves fatty liver
It can regulate lipid metabolism, reduce liver inflammation and insulin resistance.

 

5. Lowers blood pressure
It inhibits myocardial hypertrophy, dilates blood vessels, and lowers blood pressure.

 

6. Antibacterial
It inhibits Gram-positive bacteria and Plasmodium falciparum.

 

7. Promotes collagen production
It promotes collagen synthesis and alleviates psoriasis.

 

 

1. Pharmaceutical Research and Development

• Anti-tumor drugs
• Treatment of neurological diseases
• Metabolic diseases

 

2. Scientific Research and Industry
Reference standards and control samples: Used for quality control and component identification of traditional Chinese medicine.

 

3. Cosmetic Raw Materials

• Anti-aging ingredients
• Whitening ingredients

 

4. Traditional and Modern Preparations
Due to poor water solubility, it is often formulated into liposomes and nanocarriers to improve bioavailability.

 

 

Fruiterco can provide efficient and convenient delivery methods for the products that customers need. For example: air, sea, express, you can rest assured of product quality problems during transportation.

 

We have professional business staff to communicate with you about your product needs and understanding. We are a high-quality zinc citrate powder supplier in China.

 

There is a professional mailbox system, if you want to buy imperatorin, you can leave a message at any time, we will reply as soon as we see it. Contact us: Email: info@fruiterco.com.

 

 

1. Luszczki J.J., Andres-Mach M., Glensk M., Skalicka-Wozniak K. Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: A comparative study. Pharmacol. Rep. 2010;62:1231–1236.

2. Hu J., Xu C., Cheng B., Jin L., Li J., Gong Y., Lin W., Pan Z., Pan C. Imperatorin acts as a cisplatin sensitizer via downregulating Mcl-1 expression in HCC chemotherapy. Tumour. Biol. 2016;37:331–339.

3. Koziol E., Skalicka-Wozniak K. Imperatorin-pharmacological meaning and analytical clues: Profound investigation. Phytochem. Rev. 2016;15:627–649.

4. Badziul D., Jakubowicz-Gil J., Paduch R., Glowniak K., Gawron A. Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells. Mol. Cell Biochem. 2014;392:213–227.
5. Liu M., Zhang G., Zheng C., Song M., Liu F., Huang X., Bai S., Lin C., Zhu C., Hu Y., et al. Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice. Br. J. Pharmacol. 2018;175:3563–3580.