What Are The Health Benefits Of Nicotinamide Riboside?
Feb 28, 2025
What is Nicotinamide riboside?
Nicotinamide riboside powder, referred to as NR, is a natural derivative of vitamin B3 (nicotinic acid) and belongs to the nicotinamide riboside class of substances.
It is one of the key precursors for intracellular synthesis of NAD+ (nicotinamide adenine dinucleotide) and is directly converted into NAD+ through the salvage synthesis pathway. The latter is a core coenzyme for cellular energy metabolism, DNA repair, and gene expression regulation.
health benefits of nicotinamide riboside:
1. Improve NAD+ levels
NAD+ declines with age, and NR may delay aging-related metabolic decline by rapidly replenishing NAD+. Clinical trials have shown that daily supplementation of 1000mg NR can increase human NAD+ levels by more than 60%.
2. Anti-aging and cell repair
Activate Sirtuins (longevity protein family), enhance mitochondrial function and reduce oxidative stress. Animal experiments show that NR nicotinamide riboside can extend the lifespan of nematodes by 10% and improve muscle degeneration in mice.
3. Improved metabolic health
Regulate insulin sensitivity and reduce fat accumulation in obese model animals. Studies have shown that NR can improve liver lipid metabolism in patients with type 2 diabetes.
4. Neuroprotective effect
Promotes the regeneration of neuron mitochondria, and preclinical studies suggest nicotinamide riboside bulk has potential ameliorative effects on Alzheimer's disease and Parkinson's disease.
NR NAD NMN:
NR → NMN → NAD+ → breaks down into nicotinamide (NAM) → re-enters circulation (but some NAM may be lost through excretion).
| Type | NR | NMN | NAD+ |
| Chemical structure | Nucleosides (ribose + nicotinamide) | Nucleotide (ribose phosphate + nicotinamide) | dinucleotide (containing adenine) |
| Absorption path | Direct absorption | Partially degraded into NR and then enters cells | cannot pass directly through the cell membrane |
| Bioavailability | High stability and fast peak blood concentration | Requires intestinal conversion, absorption efficiency is controversial | Dependent on precursor supplementation |
| Research | More human trial data | Mainly limited to animal models | Direct supplement is invalid |
| Side effect | Occasional flushing | Potential risk of intestinal discomfort | No direct supplement possible |
Our Advantages:
Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.
Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you want to buy nicotinamide riboside, you can contact us: Email: info@fruiterco.com.
References:
1. https://www.webmd.com/vitamins/ai/ingredientmono-1560/nicotinamide-riboside
2. https://pubmed.ncbi.nlm.nih.gov/24071780/#:~:text=Nicotinamide%20riboside%20is%20a%20precursor,properties%20as%20a%20Vitamin%20B3.
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC5573990/#:~:text=Nicotinamide%20riboside%20(NR)%20is%20another,and%20yeast%E2%80%90containing%20food%20products.
4. https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-Riboside
5. https://journals.asm.org/doi/10.1128/msystems.00230-21
