Cycloastragenol Powder

 

Cycloastragenol powder is the main aglycone of astragalus saponin. Its preparation mainly uses astragaloside IV as raw material and is separated through acid hydrolysis, degradation, enzymatic hydrolysis and other methods.

 

Studies have found that cycloastragenol has a significant telomerase activating effect, thereby delaying the shortening of telomeres and ultimately playing an anti-aging effect.

 

In addition, cycloastragalus also has potential antiviral, protective lung injury, antidepressant, antihyperlipidemia and other pharmacological activities.

 

 

Analysis	Specification	Result	Test method
Physical Description
Appearance	White powder	Complies	Visual
Odor	Characteristic	Characteristic	Organoleptic
Melting point	238℃-242℃	239℃-240℃	USP40-NF35<741>
Chemical Tests
Identity	TLC	Complies	TLC
	HPLC	Complies	HPLC
Cycloastragenol	98.0% Min	99.25%	HPLC-RID
Loss on drying	1.0% Max	0.53%	USP40-NF35<731>
Residue on Ignition	1.0% Max	0.08%	USP40-NF35<281>
Heavy metals
Arsenic(MDL0.05)	1.5ppm Max	Not detected	ICP-MS
Lead(MDL0.02)	5.0ppm Max	0.06ppm	ICP-MS
Cadmium(MDL0.02)	0.3ppm Max	Not detected	ICP-MS
Mercury(MDL0.005)	0.1ppm Max	Not detected	ICP-MS
Microbiology Control
Total plate count	10,000cfu/g Max	160cfu/g	USP40-NF35<2021>
Yeast & Mold	1000cfu/g Max	0cfu/g	USP40-NF35<2021>
E. Coli	AbsEnt/10g	Absent	USP40-NF35<2022>
Salmonella	Absnt/25g	Absent	USP40-NF35<2022>
Conclusion	Complies with the standards.
General Status	Non-GMO, Non-irradiation, ISO Certificated.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Anti-aging
Activation of Telomerase and Anti-Aging Telomerase is a synthetic telomeric DNA. Activation of telomerase can slow down or even reverse the shortening of telomeres in cells, contribute to cell division and proliferation, and extend life span.

 

Therefore, regulating telomerase activity Considered the key to anti-aging, studies have found that cycloastracanol has excellent antioxidant effects.

 

2. Protect the heart
Cycloastragenol powder can improve cardiac histological changes and reduce serum levels of neuroendocrine factors such as norepinephrine, aldosterone, brain natriuretic peptide, endothelin, and angiotensin.

 

Cycloastragenol can also significantly prolong the occurrence time of arrhythmia in rats with aconitine-induced arrhythmia, reduce the duration of ventricular fibrillation, reduce the incidence of ventricular fibrillation, and prolong the survival time of animals. It has significant curative effect and few adverse reactions.

 

3. Improve cardiovascular disease
Cycloastragenol may inhibit fat production by increasing calcium ion levels in preadipocytes, suggesting that cycloastragenol can effectively control the risk factors of cardiovascular disease and is a potential drug for the treatment of obesity and hyperlipidemia.

 

4. Anti-inflammatory
Studies have found that cycloastragenol powder can inhibit palmitate from stimulating endothelial cells to induce endoplasmic reticulum stress, and reduce the hyperphosphorylation of inositol-requiring kinase 1α and the production of reactive oxygen molecules.

 

In addition, cycloastragalus can also block the activation of thioredoxin self-binding protein inflammasome by regulating adenylate-activated protein kinase, effectively inhibiting the inflammatory response and protecting cell survival.

 

5. Reduce fatty liver disease
Cycloastragenol can significantly reduce liver lipid accumulation, blood glucose, serum triacylglycerol levels and bile acid pool size in mice induced by high-fat diet by activating the transcriptional activity of FXR, and alleviate non-alcoholic syndrome induced by methionine-choline deficiency diet. Hepatic steatosis in mice with steatohepatitis.

 

 

6. Protect nerves
Studies have found that cycloastragenol powder has a protective effect on mice with cerebral ischemia injury, and can improve their neurological function scores and reduce cerebral infarction volume.

 

Further studies have found that cycloastragalus can upregulate telomerase reverse transcriptase. , TERT) expression, reducing the apoptosis of neuronal cells.

 

7. Regulate immunity
Cycloastragenol has a bidirectional regulatory effect on the immune system. On the one hand, cycloastragalus can improve the body's immune level.

 

Studies have shown that cycloastragalus can delay the shortening of lymphocyte telomeres in HIV-infected patients, increase their proliferation potential, promote the production of cytokines and chemokines and antiviral activity, and the enhanced antiviral effect is achieved through specific telomerase inhibition.

 

8. Promote wound healing
Cycloastragenol powder can promote skin wound healing and promote the proliferation and migration of fibroblasts.

 

Other studies have shown that cycloastragalus can activate the telomerase activity of neonatal keratinocytes and accelerate cell proliferation, thus promoting the healing of scratches in a single layer of neonatal keratinocytes in vitro.

 

 

Our cyclic cycloastragenol products are available in various ratios such as 4:1, 10:1, and 20:1, with a purity of up to 98%, to meet the needs of customers in different countries.

 

 

Shipping pictures, shipping country, shipping packaging

 

 

Fruiterco can provide efficient and convenient delivery methods for the products that customers need. For example: air, sea, express, you can rest assured of product quality problems during transportation.

 

We have professional business staff to communicate with you about your product needs and understanding. There is a professional mailbox system, you can leave a message at any time, we will reply as soon as we see it. If you have any product needs, you can leave a message at any time and we will reply as soon as we see it. Contact us for more details: Email: info@fruiterco.com.

 

 

 

Our products have obtained Organic, Halal, Kosher, HACCP, and USDA certifications. The company has also successfully passed ISO 22000 certification for food safety management systems. We are committed to providing our customers with high-quality products and support independent re-testing to ensure product quality.

 

 

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