Oleanolic Acid Powder

 

Oleanolic acid powder, referred to as OA, is a pentacyclic triterpene compound, white crystalline powder, odorless and tasteless. It is a natural product chemical component. It is unstable to acids and bases, is insoluble in water, and is soluble in ether and chloroform. , acetone, methanol and ethanol, etc.

 

Oleanolic acid is rich in sources and is widely present in food and herbs. For example, it exists in free form or in the form of glycosides combined with sugar in oleanolic acid, hawthorn, cloves, jujubes, loquat leaves and other plants.

 

Research has found that it has the effects of lowering lipids and blood sugar, anti-atherosclerosis, antibacterial, anti-inflammatory and antiviral, enhancing immunity, and anti-tumor effects.

 

 

ITEM	SPECIFICATION	METHOD
Physical Description
Appearance	Powder	Visual
Odor	Characteristic	Organoleptic
Taste	Characteristic	Olfactory
Particle size	95%-99%% through 80 mesh	CP2015
Chemical Tests
Oleanolic acid	≥98%	HPLC
Loss on drying	≤1.0%	CP2015 (105 oC, 3 h)
Ash	≤1.0 %	CP2015
Total Heavy Metals	≤10 ppm	CP2015
Cadmium (Cd)	≤1 ppm	CP2015(AAS)
Mercury (Hg)	≤1 ppm	CP2015(AAS)
Lead (Pb)	≤2 ppm	CP2015(AAS)
Arsenic (As)	≤2ppm	CP2015(AAS)
Microbiology
Total plate count	≤1000 CFU/g	Complies
Yeast & mold	≤100 CFU /g	Complies
E.coli	Negative	Negative
Salmonella	Negative	Negative
Salmonella	Negative	CP2015
Staphlococcus Aureus	Negative	CP2015

 

 

1. Liver protection
Studies have found that oleanolic acid has a protective effect on acute and chronic liver damage caused by a variety of chemical poisons and has anti-hepatic fibrosis effects, and its hepatoprotective mechanisms are diverse.

 

2. Anti-tumor

Research has found that oleanolic acid can act on different stages of tumorigenesis, including inhibiting tumor formation, hindering tumor induction and inducing tumor cell differentiation. It can also effectively inhibit the invasion and metastasis of angiogenesis tumor cells, and inhibit tumor cell proliferation.

 

3. Lower blood lipids
Studies have found that oleanolic acid powder has the effect of lowering blood lipids, which can significantly reduce serum cholesterol (TC) low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol ratio levels, and significantly increase high-density lipoprotein cholesterol.

 

4. Lower blood pressure
Oleanolic acid can dilate blood vessels, reduce vascular resistance, and has significant antihypertensive effects on normal and various hypertensive animals.

 

 

5. Protect nerves

A large number of studies have found that oleanolic acid powder has a neuroprotective effect. Oleanolic acid has a protective effect on isolated nerve cell damage caused by neurotoxins such as beta amyloid peptide, hydrogen peroxide, glutamate, 6-hydroxydopamine, etc.

 

6. Antibacterial

Studies have found that oleanolic acid has anti-Staphylococcus aureus, hemolytic Streptococcus, Escherichia coli, Shigella freundii, and Typhoid bacteria.

 

7. Anti-virus

Oleanolic acid powder has antiviral effects. Studies have found that OA can not only inhibit the effects of herpes simplex virus, hepatitis B virus, and hepatitis C virus, but also inhibit the replication of human immunodeficiency virus HIV-1 by directly inhibiting HIV-1 protease activity.

 

8. Anti-inflammatory
Experimental studies have reported that the anti-inflammatory effect of OA administered in multiple doses through different routes is stronger than that of a single dose, and its derivatives also have anti-inflammatory effects.

 

9. Treat osteoporosis
Studies have found that oleanolic acid has a bone-protective effect on rats with ovariectomy-induced osteoporosis. In vivo tests can increase the number of bone cells, increase the protein levels of osteocalcin and osteogenic protein 2, and can induce the differentiation of bone marrow mesenchymal stem cells into osteoblasts in vitro.

 

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