Tripterygium Wilfordii Extract

 

Tripterygium wilfordii extract is an active ingredient isolated from the roots and stems of the Celastraceae plant Tripterygium wilfordii through modern processes. The commonly used processes are: solvent extraction and supercritical extraction.

 

As a hot topic in traditional Chinese medicine and modern research, it has complex ingredients and significant pharmacological activity, but it also has certain toxicity and needs to be used with caution.

 

 

1. Diterpenoids

(1) Triptolide: The core active ingredient, with potent anti-inflammatory, immunosuppressive and anti-tumor effects.

 

(2) Triptonide: Similar in structure to acetylcholine, but with lower toxicity. Studies have shown that it is effective against psoriasis and organ transplant rejection.

 

2. Triterpenoids

Celastrol: It exerts anti-inflammatory effects by activating the heat shock protein (HSP) pathway. 

 

3. Alkaloids
Wilfordine: has immunomodulatory effects, but due to its neurotoxicity, it is currently used as a tool for pharmacological mechanism research rather than a direct drug ingredient.

 

4. Other ingredients

• Tripterygium glycosides: regulate T cell function and reduce autoimmune response.
• Lignans: has antioxidant and anti-fibrotic effects, and has potential therapeutic effects on liver and kidney fibrosis.

 

 

Items	Standards	Results
Physical Analysis
Assay	10:01	Complies
Appearance	Brown fine powder	Complies
Mesh	100% pass 80 mesh	Complies
Ash	≤ 5.0%	3.40%
Loss on Drying	≤ 5.0%	2.80%
Chemical Analysis
Heavy Metal	≤ 10.0 mg/kg	Complies
Pb	≤ 2.0 mg/kg	Complies
As	≤ 1.0 mg/kg	Complies
Hg	≤ 0.1 mg/kg	Complies
Microbiological Analysis
Total Plate Count	≤ 1000cfu/g	Complies
Yeast&Mold	≤ 100cfu/g	Complies
E.coil	Negative	Negative
Conclusion: The product conforms to the standard.

 

 

1. Rheumatoid arthritis

Tripterygium wilfordii extract has excellent anti-inflammatory and immune-regulating effects and has been approved for the treatment of rheumatoid arthritis.

 

2. Insecticidal and bacteriostatic effects
Tripterygium wilfordii can kill flies, maggots, pear star caterpillars, leaf rollers and other pests.

 

The ethyl acetate extract (T1), total alkaloids and tripterine of Tripterygium wilfordii peeled roots have inhibitory effects on Staphylococcus aureus, Bacillus subtilis and Mycobacterium 607.

 

3. Effect on smooth muscle
Tripterygium wilfordii extract has an exciting effect on rabbit uterine smooth muscle, which can strengthen the contraction of the uterus in place. It can also excite the intestinal smooth muscle of guinea pigs and strengthen the contraction of the isolated ileum.

 

 

4. Anti-tumor effect
Tripterygium wilfordii can exert anti-tumor effects through its effects on cell cycle, angiogenesis, vascular endothelial growth factors, cell proliferation and apoptosis, protein expression and cell morphology, and can be used as a potential clinical anti-cancer drug.

 

5. Neurodegenerative diseases

Triptolide and triptolide glycosides in Tripterygium wilfordii extract have certain therapeutic effects on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, experimental autoimmune encephalomyelitis, and cerebral ischemia.

 

6. Antiviral effect
Tripterygium wilfordii has an inhibitory effect on Epstein-Barr virus, herpes simplex virus type 1, measles virus, influenza A virus, etc. The mechanism may be related to inhibiting viral protein synthesis, inhibiting viral gene transcription and viral nucleic acid synthesis.

 

7. Effects on urinary system
The main effect of tripterygium wilfordii extract on kidney disease is to reduce or disappear proteinuria. Even if the effect is not significant, the macromolecular components in proteinuria can disappear after taking the drug, or the high-molecular-weight proteinuria can be converted into medium-molecular-weight proteinuria. This may Relevant to reducing the permeability of the glomerular filtration membrane.

 

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