Isoleucine Powder

 

Isoleucine powder is one of the eight essential amino acids for the human body. It can promote protein synthesis, increase growth hormone and insulin levels, maintain body balance, and increase the body's immune function.

 

It can be used to prepare complex amino acid preparations, especially for high branched chain amino acid infusions and oral liquids.

 

It can also be used as a food fortifier to balance various amino acids and improve the nutritional value of food. It can also be used to promote lactation and feed additives for dairy cows, as well as add L-isoleucine to beverages to produce functional drinks, etc.

 

 

Analysis	Specification	Result
Physical Description
Appearance	White crystals or crystalline powder	Complies
PH	5.5～7.0	6.06
Specific rotation[a]D25	+38.9°～+41.8°	40.1°
Organic volatile	Complies	Complies
Chemical Tests
Idenlification(IR)	Concordant with the reference spectrum	Complies
Assay	98.5%～101.5%	100.3%
Residual on ignition	0.3% Max	0.15%
Loss on drying	0.3% Max	0.12%
Chloride(Cl)	0.05% Max	Complies
Sulfate(SO4)	0.03% Max	Complies
Iron(Fe)	30.0ppm Max	Complies
Arsenic(As)	1.5ppm Max	Complies
Heavy metal (Pb)	15.0ppm Max	Complies
Conclusion	Complies with the USP24 Standard.
General Status	Non-GMO, Non-irradiation, ISO.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Promote protein metabolism and muscle fiber remodeling

As a key component of branched-chain amino acids (BCAA), isoleucine regulates the rate of muscle protein synthesis by activating the mTOR signaling pathway. Clinical trials have shown that daily supplementation doses of 3-5g can increase muscle fiber cross-sectional area by 12-15% in resistance training participants. Its molecular mechanisms include:

(1) Inhibit the ubiquitin-proteasome system and reduce the expression of muscle catabolism markers (such as MuRF1).
(2) Increase the activity of skeletal muscle satellite cells and promote the repair of damaged muscle fibers.
(3) Combined with leucine to enhance the phosphorylation efficiency of ribosomal S6 kinase.

 

2. Regulation of energy metabolism

In a state of glycogen depletion, isoleucine powder generates glucose through gluconeogenesis, and its metabolite acetyl-CoA can enter the tricarboxylic acid cycle to generate 36 mol ATP/mol.Exercise physiology research shows:

(1) Endurance athletes supplementing 1.2g/h isoleucine can extend the time to exhaustion by 19%.
(2) Activate skeletal muscle branched-chain amino acid dehydrogenase complex (BCKDH) to improve fatty acid oxidation efficiency.
(3) Prevent exercise-induced hypoglycemia and maintain the stability of central nervous system energy supply.

 

3. Enhance neurocognitive functions

Isoleucine, as an aromatic amino acid transport competitor, can regulate the 5-hydroxytryptamine/dopamine balance in the brain. The double-blind controlled trial found:

 

(1) 8 consecutive weeks of supplementation increased the working memory test accuracy by 23%.
(2) The density of NMDA receptors in the hippocampus increased by 17%.
(3) Movement decision-making reaction time shortened by 0.3 seconds (competitive sports scene simulation test).

 

4. Regulate immunity

By regulating the mTORC1/STAT5 signaling axis, isoleucine powder enhances:

 

(1) T lymphocyte proliferation ability.
(2) Secretion amount of NK cytotoxic granzyme B.
(3) Mucosal immunoglobulin A production rate.
(4) Supplementary experiments on marathon runners showed that the incidence of upper respiratory tract infections dropped from 42% to 11%.

 

5. Development practice of sports nutrition preparations

According to a Grand View Research report, 76% of sports drinks worldwide have added BCAAs complex formulas. Isoleucine powder application innovations include:

 

(1) Combined with coconut water electrolytes.
(2) Sustained-release microcapsule technology maintains blood drug concentration for 8-10 hours.
(3) 3:1:2 golden ratio (leucine: valine: isoleucine) combination.

 

 

1. Pharmaceutical field

L-Isoleucine is studied and used in the medical field to treat some diseases. For example, L-isoleucine supplementation is used as an adjunctive treatment in some metabolic diseases, muscle injuries, and rehabilitation processes.

 

2. Animal Husbandry

L-Isoleucine is also widely used in feed and animal husbandry. It can improve the growth performance, muscle quality and immune function of animals, and improve the production efficiency and disease resistance of livestock and poultry.

 

3. Biotechnology and Industrial Uses

Isoleucine powder also plays a role in several biotechnological and industrial applications. For example, L-isoleucine can be used as a component of the culture medium during biological fermentation and production of certain compounds.

 

 

Fruiterco is an export enterprise mainly producing plant extracts, raw materials for health care products, and raw materials for cosmetics. The company has 20+ professional service after-sales teams.

 

As long as our products are sold to North America, Europe, Australia, South America and the Middle East, the quality of our products is reliable and we have won the unanimous trust of our customers.  Contact us: Email: info@fruiterco.com.

 

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