Urolithin B Benefits, Side Effects

 

Urolithin is divided into two types: Urolithin A and Urolithin B powder. Urolithin A and Urolithin B are mainly derived from polyphenolic compounds in food, especially polyphenols in red wine.

 

When the human body ingests these foods, the polyphenolic compounds in them undergo a series of biological transformation processes and are eventually converted into urolithin A and urolithin B.

 

The metabolism of these compounds in the human body is complex and delicate, involving the participation of multiple enzymes and organelles.

 

 

Urolithin B is a naturally occurring compound extracted primarily from the following sources:

 

1. Plants: Urolithin B is widely found in many plants, especially some medicinal plants and herbs. For example, urolithin B is found in apple peels, rosemary, thyme, and nori.

 

2. Fruits and vegetables: Some common fruits and vegetables also contain urolithin B, such as apples, citrus fruits, and tomatoes.

 

3. Herbal medicine: In traditional medicine, urolithin B is commonly found in some herbs, such as astragalus and reishi.

 

 

Item	Specification	Test Method
Appearance	White to Off-white Powder	Internal
Urolithin A	≥98%	HPLC
Condition	No offensive taste and smell	Internal
Heavy Metals(Pb),ppm	≤10	GB 5009.74
Arsenic,ppm	≤1	GB 5009.11
Lead,ppm	≤1	GB 5009.12
Mercury,ppm	≤0.3	GB 5009.17
Cadmium,ppm	≤0.3	GB 5009.15
Colonies Number, CFU/g	≤1000	GB 4789.2
Yeasts & Molds, CFU/g	≤50	GB 4789.15
Salmonella SP.	0/25g	GB 4789.4
Staphylococcus	0/25g	GB 4789.10
E. Coli, MPN/g	0/25g	GB 4789.3

 

 

1. Antioxidant
Studies have found that ellagitannins and ellagic acid, the precursors of urolithins, have significant antioxidant activity. Urolithins not only have antioxidant effects, but also contribute to oxidation.

 

2. Anti-inflammatory
Colonic fibroblasts play an important role in intestinal immune response, and urolithin can significantly inhibit interleukin-1b (IL-1b) or tumor necrosis factors-a (TNF-a).

 

The induced inflammatory response of colonic fibroblasts reduces the expression level of the inflammatory factor prostaglandin E2 (PGE2), among which UroA has the strongest activity, followed by UroB, and ellagic acid has the weakest activity.

 

3. Fight cancer
Studies have shown that urolithin b supplement can effectively inhibit the proliferation of prostate cancer, colon cancer and bladder cancer cells. The distribution of urolithin in the body has significant tissue specificity.

 

For example, after consuming pomegranate juice or walnuts, the metabolite urolithin can be enriched in human prostate tissue, so it is expected to be used in the treatment of prostate-related diseases.

 

 

4. Estrogen receptor modulators
Plant-derived estrogen-like/antiestrogen substances have various effects such as regulating cholesterol levels and maintaining postmenopausal bone density. Studies have found that the special molecular structures of UroA and UroB powder make it easy to bind to α- and β-estrogen receptors.

 

However, due to their different substituents, their estrogen-like effects are also different. UroA has greater affinity for estrogen α- and β-receptors than UroB, and UroA is more likely to bind to estrogen α-receptors.

 

UroA and UroB can dose-dependently promote the proliferation of the estrogen-sensitive human breast cancer cell line MCF-7, showing weak estrogen-like effects.

 

5. Inhibit protein glycosylation
Protein glycation end products are secondary effects of hyperglycemia, which are closely related to cardiovascular and cerebrovascular diseases, diabetes, Alzheimer's disease and other diseases.

 

Studies have found that urolithin A powder and urolithin B can significantly inhibit protein glycosylation, with UroA showing a significant dose-effect relationship, while UroB does not have an obvious dose-effect relationship.

 

 

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If you have any product needs or want to buy urolithin b powder, you can leave a message at any time and we will reply as soon as we see it. Contact us for more details: Email: info@fruiterco.com.