What Are The Side Effects Of Tetrandrine?
Jun 30, 2025
What is Tetrandrine?
Tetrandrine is the main bioactive ingredient extracted from the root of Stephania tetrandra, a plant of the Menispermaceae family. It belongs to the class of bisbenzylisoquinoline alkaloids.
tetrandrine benefits:
1. Anti-tumor
It can significantly inhibit the proliferation of various cancer cells, induce tumor cell apoptosis, reduce the toxic side effects of chemotherapy, and improve the efficacy of chemotherapy drugs.
2. Protect the heart:
It has negative inotropic and negative chronotropic effects, which can reduce myocardial oxygen consumption, improve myocardial blood supply, and better protect the heart.
3. Anti-inflammatory
Tetrandrine powder can inhibit inflammatory factors, reduce redness, swelling, pain and itching, and has anti-inflammatory effects.
4. Antibacterial
It can inhibit bacterial and fungal infections and promote skin wound healing.
5. Anti-aging
It has a good effect of scavenging free radicals, delaying skin aging and improving elasticity.
6. Ophthalmological diseases
It can be used to treat ocular inflammation, including uveitis, keratitis and the resulting retinal diseases.
7. Kidney detoxification
Tetrandrine has a significant antagonistic effect on acute nephrotoxicity caused by streptomycin.
side effect:
1. Hepatotoxicity and renal toxicity
Long-term or excessive use may cause liver cell damage, manifested as elevated transaminase, jaundice, and a higher risk of renal damage, especially at high doses.
2. Nervous system reactions
Mild drowsiness, fatigue, tremor, muscle paralysis in a few cases, respiratory depression in severe cases.
3. Allergic and skin reactions
Rash, pigmentation.
4. Contraindications for special populations
Pregnant women and lactating women are prohibited; people with spleen and stomach deficiency should use with caution; people with allergic constitutions need to try it in advance.
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References:
1. https://pubmed.ncbi.nlm.nih.gov/26899361/#:~:text
2. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/tetrandrine#:~:text
3. https://www.caymanchem.com/product/19874/tetrandrine
4. https://www.sciencedirect.com/science/article/abs/pii/S0031942216300218#:~:text
5. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/tetrandrine
6. https://synapse.patsnap.com/article/what-is-tetrandrine-used-for
7. https://go.drugbank.com/drugs/DB14066






