What Is Spermidine And How Is It Different From Spermidine Trihydrochloride?

 

Spermidine powder is a natural polyamine compound, which is converted from putrescine by spermidine synthase. It is widely involved in life processes such as cell proliferation, autophagy and DNA stability.

 

Sources of spermidine:

 

1. Natural food

• Plants: wheat germ, soybeans, mushrooms, durian.
• Animal: bluefin tuna liver, natto, cheese.

 

2. Industrial preparation

• Microbial fermentation: using gene-edited high-yield strains of Escherichia coli, the fermentation efficiency reaches 25 g/L.
• Chemical synthesis: using putrescine and S-adenosylmethionine (SAM) as raw materials, produced by enzyme immobilization reaction, with a purity of ≥99.5%.

 

3. Human synthesis
Intestinal flora: About 30% of wheat germ spermidine is produced by the metabolism of intestinal Bacteroides and Lactobacillus.

 

 

1. Autophagy activation
It activates the AMPK/mTOR pathway and removes aging proteins in cells by simulating the effects of calorie restriction.

 

2. Anti-aging
It can extend the lifespan of yeast and nematodes by 20%-30%. Human cohort studies have shown that people who eat a high spermidine diet are 5-8 years younger in terms of physiological age.

 

3. Neuroprotection
It can promote neuronal synaptic plasticity and reduce the Aβ plaque density of Alzheimer's disease model mice by 40%.

 

 

Characteristic	Spermidine	Spermidine Trihydrochloride
Molecular formula	C7H19N3	C₇H₁₉N₃·3HCl
Structural features	Free alkaline polyamine containing 3 amino groups	Spermidine bound to 3 hydrochloric acid molecules
Stability	It needs to be stored at -20℃ away from light. It easily absorbs moisture and degrades at room temperature.	Degradation rate <5% after 2 years of storage at room temperature, high temperature resistant
Solubility	Slightly soluble in water, pH sensitive	Highly water soluble, stable at pH 3-7

 

 

1. Absorption efficiency

• Spermidine: Oral bioavailability is only 12%-15%.
• Spermidine trihydrochloride: Its absorption rate is 35%-40%.

 

2. Core applications

(1) Wheat germ extract spermidine:

• Laboratory research: Added to cell culture medium to activate the autophagy pathway.
• In vitro experiments: Combined with liposomes for enhanced gene transfection.

 

(2) Spermidine Trihydrochloride:

• Anti-aging health products: 0.3-1.2 mg/kg daily dose.
• Drug carrier: Targeting tumor cell autophagy.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you want to buy spermidine, you can contact us: Email: info@fruiterco.com.

 

 

1. https://www.sciencedirect.com/science/article/abs/pii/S0308814624030589

2. https://www.linkedin.com/pulse/depth-review-spermidine-trihydrochloride-powder-phcoker

3. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/spermidine

4. https://www.webmd.com/vitamins/ai/ingredientmono-1500/fermented-wheat-germ-extract

5. https://neuroganhealth.com/blogs/news/spermidine-foods

6. https://pmc.ncbi.nlm.nih.gov/articles/PMC8612618/

7. https://pmc.ncbi.nlm.nih.gov/articles/PMC6287690/

8. https://pmc.ncbi.nlm.nih.gov/articles/PMC6637774/

9. https://countrylifefoods.com/blogs/country-life-feed/wheat-germ-vs-wheat-bran-which-one-is-best-for-you

10. https://www.wikihow.com/Eat-Wheat-Germ