Honokiol Magnolia Bark Extract

 

Honokiol magnolia bark extract is a natural active ingredient extracted from the bark or branches of the Chinese medicine Magnolia officinalis, which belongs to the lignan class of compounds.

 

The main components of Magnolia bark are Honokiol and Magnolol, which have a wide range of pharmacological effects and are used in both traditional and modern medicine.

 

 

1. Honokiol:
Molecular formula C18H18O2, has anti-inflammatory, antioxidant, neuroprotective and other effects, and can easily penetrate the blood-brain barrier.

 

2. Magnolol:
It is an isomer with honokiol, with the same molecular formula but slightly different activities due to structural differences. The main effects are antibacterial, anti-tumor.

 

3. Other ingredients:
It may contain a small amount of volatile oils (such as β-eucalyptol), polysaccharides and flavonoids, which synergistically enhance the efficacy.

 

 

Analysis	Specification	Result	Test method
Physical Description
Appearance	White fine powder	Complies	Visual
Odor & Taste	Characteristic	Characteristic	Organoleptic
Particle size	98% pass 80 mesh	Complies	80 Mesh Screen
Extract Solvent	Ethanil & water	Complies	/
Bulk density	50-60g/100ml	55g/100ml	/
Chemical Tests
Assay (Honokiol)	98.0% Min	98.33%	HPLC
Loss on drying	1.0% Max	0.12%	5g/105℃/2hrs
Ash content	1.0% Max	0.34%	2g/525℃/3hrs
Solvent residue	Eur. Pharm	Complies	/
Pesticide residue	Negative	Negative	/
Heavy metals	10.0ppm Max	Complies	AAS
As	2.0ppm Max	Complies	AAS
Pb	2.0ppm Max	Complies	AAS
Microbiology Control
Total plate count	1,000cfu/g Max	Complies	AOAC
Yeast & Mold	100cfu/g Max	Complies	AOAC
E. Coli	Negative	Negative	AOAC
Salmonella	Negative	Negative	AOAC
Staphylococcus	Negative	Negative	AOAC
Conclusion	Complies with the standards.
General Status	Non-GMO, Non-irradiation, ISO Certificated.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Anti-inflammatory
Honokiol magnolia bark extract can inhibit the NF-κB pathway, reduce chronic inflammation, and have a certain relieving effect on chronic inflammation such as arthritis and enteritis.

 

2. Protect nerves
It can promote the activity of GABA receptors in the brain, relieve anxiety and depression; studies have shown that it may improve Alzheimer's disease.

 

3. Antioxidant
It can be added to cosmetics to effectively remove free radicals, protect cells from oxidative damage, delay skin aging, and have obvious antioxidant and anti-aging effects.

 

4. Antibacterial
Honokiol magnolia bark extract has an inhibitory effect on Staphylococcus aureus, Candida albicans, etc. Some studies suggest the potential of anti-HSV-1 virus, but more research data is needed to prove it.

 

5. Auxiliary anti-tumor
It inhibits the proliferation of cancer cells by inducing apoptosis, such as effective in in vitro experiments on breast cancer and liver cancer.

 

 

• Medicine: Chinese medicine raw materials, anti-anxiety drugs, anti-tumor adjuvants.
• Health products: dietary supplements to enhance immunity and improve sleep.
• Daily chemicals: added to anti-acne skin care products or oral care products.

 

 

Feature	Honokiol magnolia bark extract	Magnolol
hydroxyl position	The two phenolic hydroxyl groups are located at the 3' and 5 positions of the biphenyl structure.	The two phenolic hydroxyl groups are located at the 3 and 5 positions of the biphenyl structure.
Solubility	The molecular polarity is slightly lower and the fat solubility is stronger	Slightly higher polarity, slightly better water solubility than honokiol
Stability	Easier to cross the blood-brain barrier	High stability in the gastrointestinal environment
Protect nerves	Stronger effect, anti-anxiety, anti-depression, nerve regeneration	The effect is relatively weak, mainly sedative
Anti-tumor	Outstanding effect on breast cancer and glioma	The inhibitory effect on colon cancer and liver cancer is more significant
metabolic effects	Regulate lipid metabolism and reduce triglycerides	Improve insulin resistance
Toxicity	Lower (LD₅₀ is higher)	Higher doses may cause elevations in liver enzymes

 

Differences in application scenarios:

1. Honokiol magnolia bark extract:

• Adjuvant treatment for neurological diseases, such as Alzheimer's disease and anxiety disorder;
• High value-added health products, can improve sleep and help brain health.

 

2. Magnolol:

• Digestive system diseases, such as gastritis and irritable bowel syndrome;
• Daily chemical products, can be used in antibacterial toothpaste and acne topical preparations.

 

 

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