Sakae NAA Combretum Quadrangulare Extract

 

Sakae NAA combretum quadrangulare extract is mainly derived from the Combretum plant, and the main active ingredients are:

 

1. Polyphenol complex (accounting for 24-31% of dry weight)

• Corilagin: inhibits TLR4/MyD88 signaling pathway and reduces IL-6 expression by 67%.
• Ellagic acid derivatives: activates the Nrf2 pathway to increase SOD activity by 2.3 times.
• Proanthocyanidin B type dimer: blocks NF-κB nuclear translocation and inhibits iNOS production.

 

2. Characteristic triterpenes

• Combretastatin A-4 analogues: selectively destroy the microtubule structure of tumor vascular endothelial cells.
• Oleanolic acid type triterpenoid saponins: enhances macrophage phagocytosis index by 189%.

 

3. Trace element spectrum

• Organic germanium (12.8ppm): induces interferon γ secretion.
• Selenomethionine (0.45μg/g): as a GPx enzyme cofactor.

 

 

Product Name: Combretum Quadrangulare Extract		Botanical Source: Combretum alfredii Hance
Batch No.: LSM211106		Quantity: 900KGS
Manufacture Date: Nov 06, 2024	Analysis Date: Nov 07, 2024		Expiration Date: Nov 05, 2026

 

Analysis	Specification	Result	Test method
Physical Description
Appearance	Brown yellow powder	Complies	Visual
Odor	Characteristic	Characteristic	Organoleptic
Particle Size	100% pass 80mesh	Complies	80 Mesh Screen
Chemical Tests
Assay	10:1	10:1	TLC
Loss on drying	5.0% Max	2.12%	5g/105℃/2hrs
Residue on Ignition	5.0% Max	3.25%	2g/525℃/3hrs
Heavy Metals	10ppm Max	Complies	AAS
As	1ppm Max	0.15ppm	AAS
Pb	2ppm Max	0.47ppm	AAS
Hg	1ppm Max	0.08ppm	AAS
Microbiology Control
Total Plate Count	1,000cfu/g Max	Complies	AOAC
Yeast & Mold	100cfu/g Max	Complies	AOAC
Coli	Negative	Negative	AOAC
Salmonella	Negative	Negative	AOAC
Conclusion	Complies with the standards.
General Status	Non-GMO, Irradiation sterilization, ISO & Kosher Certificated.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Regulate metabolism

• Blood sugar regulation: In a rat model of type 2 diabetes, a dose of 200 mg/kg reduced fasting blood sugar by 41%, and the mechanism involved enhanced phosphorylation of PPARγ receptors.
• Lipid remodeling: By activating the AMPK pathway, liver lipid accumulation was reduced by 53%, and a phase II clinical trial showed an average waist circumference reduction of 4.2 cm.

 

2. Anti-inflammatory

• Rheumatoid arthritis: sakae NAA combretum quadrangulare extract inhibits the activity of MMP-13 metalloproteinases, and the DAS28 score in a double-blind trial was reduced by 1.8 points.
• Intestinal inflammation regulation: Regulates the balance of Th17/Treg and increases the IL-10 level in colon tissue by 3.1 times.

 

3. Anti-pathogenic microbial spectrum

• Anti-malarial parasites: IC50 for chloroquine-resistant strain PfK1 = 0.76 μg/mL, and the mechanism of action involves interference with heme crystallization.
• Oral pathogens: The clearance rate of biofilm of Fusobacterium nucleatum is 91%, and the EC50 value is 2 orders of magnitude lower than that of chlorhexidine.

 

4. Protect nerves

• Increase the expression of BDNF in the hippocampus by 2.9 times.
• Sakae NAA combretum quadrangulare extract inhibits the oligomerization of amyloid-β protein.
• Preclinical studies have shown that the Morris water maze scores of vascular dementia model mice were improved by 38%.

 

5. Protect skin health

• Inhibit tyrosinase activity.
• Promote type I collagen synthesis.
• Human trials have shown that the area of ​​UVB-induced erythema is reduced by 49%.

 

 

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Our products are certified organic, halal, kosher, USDA. Our company has passed ISO22000 quality management system certification. We are able to provide our customers with high-quality products and support them in retesting ingredients to ensure product quality.

 

 

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