DL Pyroglutamic Acid

 

DL pyroglutamic acid is the racemic form of pyroglutamic acid, which is a mixture of D-type and L-type. Its chemical formula is C₅H₇NO₃ and its molecular weight is 129.11.

 

 

Analysis	Specification	Result
Assay	98.5%～101.5%	99.8%
Physical & Chemical Tests
Appearance	White crystalline powder	Complies
Solubility	Water soluble	Fully water soluble
Specific rotation[]D20	+6.3°～+7.3°	+6.7°
Loss on drying	0.30% Max	0.08%
Residue on ignition	0.10% Max	0.07%
Heavy metals	10ppm Max	<10ppm
Microbiology Control
Total plate count	5000cfu/g Max	<5000cfu/g
Yeast & Mold	500cfu/g Max	<500cfu/g
Conclusion	Complies with the in-house standard.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Antiviral Effects
As an inactivator of hepatitis B surface antigen, DL pyroglutamic acid effectively inactivates vaccinia virus, herpes simplex virus, and influenza virus. A concentration of 0.025–0.05% achieves 100% antigen inactivation.

 

2. Neuromodulatory Effects
It may inhibit GABA transaminase, increase brain γ-aminobutyric acid (GABA) levels, and reduce myoclonic jerks and EEG spikes in epilepsy models.

 

3. Antioxidant
It scavenges free radicals, reduces oxidative stress and chronic inflammation, and potentially reduces the risk of cardiovascular and neurodegenerative diseases.

 

4. Moisturizing and Skin Repair
DL pyroglutamic acid is naturally present in the skin's moisturizing factor, boasting superior moisturizing properties compared to glycerin and propylene glycol. It is non-irritating, softens keratin, and strengthens the skin barrier.

 

 

1. Pharmaceutical and Biological Research

• Antiviral Agents
• Nervous System Drugs
• Pharmaceutical Intermediates

 

2. Cosmetics and Personal Care

• High-Performance Moisturizer: Added to creams and serums
• Functional Additive: DL pyroglutamic acid can repairs hair cuticles in hair care products and softens cuticles in nail care products.

 

3. Food and Feed Industry

• Nutritional Supplements
• Flavor Modifiers

 

4. Chemical Engineering and Materials Synthesis

• Chiral Synthesis Sources: Preparation of optically active pesticides and β-lactam antibiotics.
• Surfactants: Derivatives are used in detergents to improve cleaning performance and gloss.

 

 

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