L Phenylalanine Powder

 

L phenylalanine powder is one of the essential amino acids for the human body, with the chemical formula C₉H₁₁NO₂. Its unique aromatic ring structure enables it to play a key role in protein synthesis, neurotransmitter metabolism and signal transduction.

 

 

1. Natural isomers

(1) L-phenylalanine
Natural form, involved in protein biosynthesis, cannot be synthesized by the human body, and must be ingested through diet (meat, beans, dairy products) or supplements.

It is the only biologically active configuration, directly involved in the production of key metabolites such as tyrosine and dopamine.

 

(2) D-phenylalanine
Non-natural configuration, must be obtained through chemical synthesis or microbial transformation, does not participate in protein synthesis, but has the potential to inhibit neuropeptidase activity, which may prolong the duration of action of endogenous analgesics.

 

2. Synthetic derivatives

 

(1) DL-phenylalanine

L phenylalanine powder and a racemic mixture of D-phenylalanine are commonly used in chronic pain management and work through a dual mechanism.

 

(2) N-acetylphenylalanine
Acetylation modification improves blood-brain barrier penetration and is used in experimental treatment of Parkinson's disease.

 

 

Analysis	Specification	Result
Physical Description
Appearance	White crystalline powder	White crystalline powder
Loss on drying	0.30% Max	0.17%
Residue on ignition	0.40% Max	0.08%
Specific rotation	-33.2° ~ -35.2°	- 33.6°
PH	5.4-6.0	5.7
Chemical Tests
Identification test	Infrared absorption	Complies
Assay	98.5~101.5%	99.5%
Chloride(Cl)	0.05% Max	<0.05%
Sulfate(SO4)	0.03% Max	<0.03%
Iron(Fe)	0.03% Max	<0.03%
Heavy metals (Pb)	15.0 ppm Max	10.0 ppm
Conclusion	Complies with the USP32 Standard.
General Status	Non-GMO, ISO Certificate.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Neurotransmitter synthesis center

• Dopamine/epinephrine precursor: tyrosine is generated by tyrosine hydroxylase, and then further converted into dopamine, norepinephrine and epinephrine to regulate emotions, attention and stress response.

 

• 5-HT indirect effect: by regulating the activity of tryptophan transporters, it indirectly affects 5-HT synthesis.

 

2. Regulate metabolism

• Gluconeogenesis and energy supply: L phenylalanine powder is converted into pyruvate in the liver, participating in glucose regeneration and maintaining fasting blood sugar stability.

 

• Phenylalanine hydroxylase pathway: defects lead to phenylketonuria, which requires a lifelong low-phenylalanine diet. The latest gene therapy AAV-PAH has entered Phase III clinical trials.

 

3. Clinical application

• Antidepressant adjuvant: Combination with SSRI drugs can increase the treatment response rate by 18%, and the mechanism is related to the activation of the dopaminergic system.

 

• Chronic pain management: DLPA reduces opioid dependence by inhibiting endorphin degradation, and the pain score of fibromyalgia patients is reduced by 30%.

 

• Skin repair enhancement: Topical phenylalanine derivatives can inhibit tyrosinase activity and reduce melanin production, and are used for the treatment of chloasma.

 

4. Exercise and immune support

• Muscle protein synthesis: L phenylalanine powder promotes muscle fiber repair after exercise, and combined with leucine can increase the synthesis rate by 22%.

 

• Immune cell proliferation: As an essential substrate for T lymphocyte activation, its deficiency leads to Th1/Th2 imbalance.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. Email: info@fruiterco.com.

 

 

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