Pentapeptide-3

 

Pentapeptide-3 is a neurotransmitter-inhibiting peptide. It is a pentapeptide fragment derived from waglerin-1, a neurotoxin found in cobra venom.

Amino Acid Sequence: Composed primarily of glycine, proline, arginine, and alanine; the sequence is H-Gly-Pro-Arg-Pro-Ala-NH2. It typically appears as a white to off-white solid.

 

Mechanism of Action: Acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), it blocks nerve signals at the postsynaptic membrane and inhibits sodium ion release, thereby inducing muscle relaxation. Its site of action is similar to that of curare (used in poison arrows), yet it is safer and gentler when used as a topical ingredient.

 

 

Items	Standards	Results
Appearance	White to off-white powder	Complies
Identity by ESI-MS	Theoretical MW: Complies	Complies
Purity(HPLC)	≥98.0%	99.44%
Water(K.E)	≤7.0%	6.04%
Conclusion	Conforms to standard	Complies
Store	Keep in dark and cool dry place(-20 to 8°C).

 

 

1. Softens expression lines

It inhibits the release of neurotransmitters and reduces facial muscle contractions, smoothing out existing wrinkles.

 

2. Anti-wrinkle

It improves the organization of collagen and elastin fibers, acting directly on the dermis to stimulate collagen production and enhance skin elasticity, thereby significantly reducing wrinkle depth.

 

3. Anti-inflammatory and antioxidant

Pentapeptide-3 regulates the Nrf2/ARE signaling pathway to scavenge free radicals and inhibits the NF-κB inflammatory pathway to reduce the release of pro-inflammatory factors. It alleviates redness and post-inflammatory hyperpigmentation, making it suitable for anti-aging care for sensitive skin.

 

4. Improves skin tone

It regulates pigmentation to correct uneven skin tone while boosting the skin's self-repair capabilities. It enhances skin luminosity and maintains a healthy skin barrier.

 

 

1. Daily Skincare Products:

Used as a key active ingredient in anti-wrinkle creams, serums, facial masks, and moisturizers, it helps diminish expression lines such as crow's feet, forehead lines, and nasolabial folds. It carries a low safety risk rating (1) in cosmetics, is non-comedogenic, and is generally considered safe for use by pregnant women.

 

2. Medical Aesthetic Recovery:

In post-procedure recovery products-such as those used after laser spot removal or skin resurfacing-Pentapeptide-3 helps accelerate wound healing and enhances the skin tissue's capacity for self-repair and regeneration.

 

3. Biopharmaceuticals and Scientific Research:

As a bioactive peptide, it is utilized in research on cell signaling mechanisms, helping scientists gain deeper insight into the physiological processes of skin cells and thereby develop novel therapies for skin disorders.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. Email: info@fruiterco.com.

 

 

 

Our products have obtained Organic, Halal, Kosher, HACCP, and USDA certifications. The company has also successfully passed ISO 22000 certification for food safety management systems. We are committed to providing our customers with high-quality products and support independent re-testing to ensure product quality.

 

 

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