Semaglutide Raw Powder

 

Semaglutide raw powder is the physical form of semaglutide API, mainly used to make oral or injectable preparations.

 

Note: for research use only

 

 

ITEMS	SPECIFICATIONS	RESULTS
Appearance	White or almost white loose powder	White loose powder
Solubility	Freely soluble in water; Firstly,to add freshly boiled and cooled water to make a clear solution containing 0.15mg of semaglutide in 1ml.Then,to adjust the pHof the solution to 5.5 with 0.05M hydrochloric acid and keep for 30 secondsFinally,to adjust the pH of the solution to 3.0 and keep 30 seconds.The solution should be turbid in the rang of pH 3.0 to 5.5.	Conforms
Specific optical rotation[a]²D	-15.0°to-10.0°(anhydrous and sodium ion-free substance,C=10mg/ml,H₂O)	-13.9°
Identification By HPLC	The retention time of the principal peak of the test solution corresponds to that of the reference solution,as obtained in the Assay.	Conforms
Molecular Ion Mass	4113.58±1.0	Conforms
Amino acid contect	Asp:0.9-1.1 Ser:2.7-3.3 Glu:4.5-5.5 Gly:3.6-4.4 His:0.9-1.1 Arg:1.8-2.2 Thr:1.8-2.2 Ala:2.7-3.3 Aib:0.9-1.1 Tyr:0.9-1.1 Val:1.8-2.2 Lys:0.9-1.1 Ile:0.9-1.1 Leu:1.8-2.2 Phe:1.8-2.2 AEEA:Should be detected	1.0 3.0 5.0 4.0 1.0 2.0 2.0 3.0 1.1 1.0 1.9 1.0 1.0 2.0 2.0 Conforms
pH	7.0-9.0	7.5
Water Content (K.F)	NMT 8.0%	5.3%
Solution clarity and color	Clear and colorless	Conforms
Related substances(HPLC)	Impurity A:NMT0.3% Impurity D:NMT0.3% Impurity E:NMT 0.1% Any individual impurity:NMT 0.1% Total impurities:NMT1.5%	N.D N.D N.D 0.06% 0.3%
Related substances(HPLC)	Impurity B:NMT0.1% Impurity C:NMT0.1%	0.02% 0.05%
Sodium ion	1.5%～4.0%	2.2%
High molecular protein	NMT 0.5%	0.03%
Residual solvent	Methylene chloride NMT 600ppm Acetonitrile NMT 410ppm Methanol NMT 3000ppm DMF NMT880ppm Isopropyl ether NMT 5000ppm Isopropanol NMT 5000ppm	N.D 12ppm N.D N.D N.D N.D
Bacterial Endotoxins	NMT 10EU/mg	Conforms
Microbial Limits	TAMC NMT 200cfu/g TYMC NMT 100cfu/g	<10cfu/g <10cfu/g
Acid group ions	Trifluoroacetate ion NMT0.1% Phosphate ion NMT 0.1% Chloride ion NMT 0.1% Acetate ion NMT 0.1%	N.D N.D 0.01% N.D
Assay	95.0%-105.0%(Calculated with reference to the anhydrous and sodium ion-free substance.	100.0%
Storage	Keep in tight container,protect from light,store at a temperature of-20±5℃.
Conclusion: This batch of product complies with Enterprise Standard.

 

 

1. Treatment of Type 2 Diabetes

• As a GLP-1 receptor agonist, it effectively lowers blood sugar by stimulating insulin secretion and inhibiting glucagon release.
• It can also reduce cardiovascular risk and the risk of myocardial infarction in patients with diabetes.

 

2. Pharmaceutical Ingredients
Semaglutide raw powder must be processed through pharmaceutical manufacturing into oral tablets or injections and should not be taken directly.

 

3. Weight Loss
At higher doses, it can aid in weight management in obese (BMI ≥ 30) or overweight (BMI ≥ 27 and comorbidities) patients by increasing satiety and delaying gastric emptying.

 

 

1. Common Side Effects:

• Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, abdominal distension, and constipation, often occur initially and gradually subside with treatment.
• Risk of Hypoglycemia: Monitor blood glucose levels, especially when used with sulfonylureas or insulin.

 

2. Rare but Serious Side Effects:

• Pancreatitis: Severe abdominal pain and vomiting require immediate medical attention.
• Thyroid Tumor Risk: Semaglutide raw powder may increase the risk of thyroid C-cell tumors. Use is contraindicated in patients with medullary thyroid carcinoma or multiple endocrine neoplasia.

 

3. Other Potential Risks:
Cholelithiasis, worsening renal function, and retinopathy.

 

4. Contraindications:

This product is contraindicated in patients with a history or family history of thyroid cancer, active pancreatitis, pregnancy/lactation, or severe renal insufficiency.

 

 

Our products are certified HACCP, Halal, and Kosher. Our company has passed ISO22000 quality management system certification. We can provide customers with the products they need and provide efficient and convenient transportation methods. For example: air transport, sea transport, express delivery, you can rest assured if product quality problems occur during transportation.

 

We have professional business personnel to communicate with you to understand your needs and understanding of the product. There is a professional email system, you can leave a message at any time, and we will reply as soon as we see it. Email: info@fruiterco.com.

 

 

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