Does Phyllanthus Niruri Extract Offer Liver-Protecting Benefits?

 

Phyllanthus urinaria extract is a concentrate of active constituents derived from the whole plant of *Phyllanthus*, rich in compounds such as flavonoids, lignans, phenolic acids, and alkaloids.

 

 

1. Liver Protection

• Antiviral Activity: Significantly inhibits the replication of the Hepatitis B virus (HBV), reducing serum levels of viral DNA and DNA polymerase; clinically used as an adjunct therapy for chronic Hepatitis B.
• Liver Injury Repair: Alleviates hepatocyte damage induced by toxins such as carbon tetrachloride (CCl₄), lowers levels of transaminase (ALT) and malondialdehyde (MDA), and preserves the integrity of hepatocyte membranes.
• Anti-fibrotic and Anti-carcinogenic Effects: Inhibits the proliferation of liver cancer cells, reduces alpha-fetoprotein synthesis, and aids in the prevention of primary liver cancer.

 

2. Broad-Spectrum Antibacterial Activity

It exerts inhibitory effects against common pathogens such as *Staphylococcus aureus*, *Escherichia coli*, and *Shigella dysenteriae*, with a minimum inhibitory concentration (MIC) as low as 2.34 mg/L.

 

3. Anti-inflammatory Activity

Phyllanthus urinaria extract powder inhibits prostaglandin synthesis, thereby alleviating symptoms associated with arthritis and soft tissue swelling.

 

4. Antioxidant Properties

It is rich in flavonoids, which effectively neutralize free radicals and delay cellular oxidative damage.

 

5. Weight Loss

It inhibits the differentiation of fat cells and the accumulation of triglycerides, thereby aiding in the treatment of obesity.

 

6. Diuretic and Anti-swelling Effects

It promotes renal water excretion, helping to alleviate edema associated with nephritis as well as ascites caused by liver cirrhosis.

 

 

1. Pharmaceutical Sector

• Treatment of Liver Diseases
• Anti-infectives
• Topical Preparations

 

2. Health Foods

• Teas/Decoctions: Dried *Phyllanthus* leaves are steeped in water or simmered in soups to clear liver heat, improve vision, relieve summer heat, and treat diarrhea.
• Liver-Support Supplements: Incorporated as a hepatoprotective ingredient in dietary supplements.

 

3. Cosmetics

Phyllanthus urinaria powder are utilized in moisturizing and anti-inflammatory formulations to alleviate skin dryness and sensitivity.

 

4. Agricultural Sector

It acts to inhibit pathogens affecting crops.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you would like to buy phyllanthus urinaria extract, please contact us: Email: info@fruiterco.com.

 

 

1. Chang C. C., Lien Y. C., Liu K. C., Lee S. S. (2003). Lignans from Phyllanthus urinaria. Phytochemistry 63 (7), 825–833. 10.1016/s0031-9422(03)00371-6

2. Chen Z.-L., Zhang R. (2023). Suppressed effects of Phyllanthus urinaria L. ethyl acetate extract on hepatitis B virus both in vitro and in vivo . Precis. Med. Res. 5 (3), 15. 10.53388/pmr20230015

3. Cheng H. Y., Yang C. M., Lin T. C., Lin L. T., Chiang L. C., Lin C. C. (2011). Excoecarianin, isolated from Phyllanthus urinaria linnea, inhibits herpes simplex virus type 2 infection through inactivation of viral particles. Evid. Based Complement. Altern. Med. 2011, 259103. 10.1093/ecam/nep157

4. Chularojmontri L., Ihara Y., Muroi E., Goto S., Kondo T., Wattanapitayakul S. K. (2009). Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells. J. Med. Assoc. Thai 92 (Suppl. 3), S43–S51.

5. https://www.health.com/chanca-piedra-8639715

6. Deng G.-H., Chen S., Wang H., Gao J., Luo X., Huang H. (2012). Determination of active ingredients of Phyllanthus urinaria by capillary electrophoresis with amperometric detection. J. Liq. Chromatogr. Relat. Technol. 35 (17), 2370–2380. 10.1080/10826076.2011.631264