What Are The Benefits And Uses Of Papaya Leaf Extract?
May 18, 2026
what is Papaya Leaf Extract?
Papaya leaf extract is made from papaya leaves through specific processes (such as enzymatic hydrolysis, concentration, and spray drying) to produce powder or extract. Its quality depends on leaf maturity and processing techniques.
Core active ingredients:
- Alkaloids (0.4%): Papain, pseudopapain, dehydropapain I/II, choline, etc.
- Enzymes: Papain, papain chymopapain.
- Flavones and phenols: Quercetin, rutin, etc.
- Amino acids and polysaccharides: Contains 17 amino acids including asparagine and leucine, and immunomodulatory polysaccharides.
- Carotenoids
- Vitamin C/E
- Trace elements
papaya leaf extract benefits and uses:
1. Health Supplements
- Digestive System Regulation: Relieves bloating and acid reflux, increases pepsin activity by 28.6%.
- Metabolic Syndrome Intervention: Reduces postprandial blood glucose fluctuations, decreases waist circumference by 4.2cm.
- Liver Protection: Reduces transaminase levels by 28.6%, inhibits liver fibrosis.
- Immune Enhancement: Promotes T lymphocyte proliferation and IL-2/IL-4 secretion, aiding in anti-infection efforts.
2. Adjunctive Treatment for Diseases
- Anti-tumor: Inhibits the growth of various cancer cells, including cervical cancer and liver cancer, and induces apoptosis in cancer cells.
- Antiviral and Antibacterial: Shows a 91.2% inhibition rate against Staphylococcus aureus and has potential anti-HIV-1 activity.
- Joint and Skin Repair: Reduces arthritis pain and promotes wound healing.
3. Cosmetics
Papaya leaf extract powder can inhibit tyrosinase activity by 67.4%, reducing pigmentation; when added to skincare products, it can increase moisturizing rate by 65%.
4. Contraindications
- Pregnant women
- Those taking anticoagulants
5. Adverse Reactions
Overdose may cause diarrhea; long-term use requires monitoring of iron absorption.
About us:
Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.
Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you would like to buy papaya leaf extract, please contact us: Email: info@fruiterco.com.
References:
1. https://www.healthline.com/nutrition/papaya-leaf#The-bottom-line
2. https://www.webmd.com/vitamins/ai/ingredientmono-488/papaya#dosing
3. Hettige S. Salutary effects of Carica papaya leaf extract in dengue fever patients-a pilot study. Sri Lankan Family Physician. 2008;29(1):17-19.
4. Dharmarathna S, Wickramasinghe S, Waduge RN, Rajapakse R, Kularatne S. Does Carica papaya leaf extract increase the platelet count? An experimental study in a murine model. Asian Pac J Trop Biomed. 2013. 3(9):720-724.
5. Sathasivam K, Ramanathan S, Mansor SM, Haris MR, Wernsdorfer WH. Thrombocyte counts in mice after the administration of papaya leaf suspension. Wien Klin Wochenschr. 2009;121(3):19-22.
6. Patil S, Shetty S, Bhide R, Narayanan S. Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats. J Pharmacogn Phytochem. 2013;1(5):57-60.






