What Are The Health Benefits And Uses Of Amentoflavone?

 

Amentoflavone is a naturally occurring biflavonoid compound, primarily found in the following plants:

 

• Plants of the genus Selaginella: for example, selaginella tamariscina.
• Cunninghamia lanceolata: a medicinal constituent present in the branches and foliage of the Chinese fir (a member of the cypress family).
• Cypress trees: the leaves of these trees contain this type of flavonoid substance.

 

 

1. Anti-Aging

Experiments on nematodes have demonstrated that, when used alone, it can extend lifespan by 63.81%, activate the DAF-16/FOXO transcription factor, and enhance the antioxidant defense system.

 

2. Antioxidant Properties

Amentoflavone powder can scavenge DPPH free radicals with an efficiency of up to 92.3% and reduce lipid peroxidation.

 

3. Cardiovascular Protection

• Improves vascular function: Increases nitric oxide production in vascular endothelial cells, mitigates vasoconstriction, and alleviates cardiovascular impairments induced by high-sugar and high-fat diets.
• Lipid-lowering effects: Clinically utilized to reduce blood lipids, clear metabolic turbidity, and aid in the prevention and treatment of atherosclerosis.

 

4. Anti-Inflammatory Properties

It can block NF-κB activation and COX-2 expression, and inhibit TNF-α levels by 78.6%.

 

5. Anti-Cancer Mechanisms

Selaginella tamariscina extract amentoflavone can induce apoptosis in breast cancer cells and help maintain vascular health.

 

6. Blood Glucose Regulation

Animal studies have confirmed that it can reduce fasting blood glucose levels by 18.6% and improve insulin resistance.

 

7. Regulation of Lipid Metabolism

When combined with synephrine, it can be used in weight management products.

 

 

1. Pharmaceutical R&D

• Anti-Pulmonary Fibrosis: As a PDE4 inhibitor, it mitigates lung tissue damage.
• Anti-Cancer Formulations: Formulated in combination with compounds such as Swertiamarin to target liver and gastric cancers.
• Neuroprotection: Inhibits GABA activity, demonstrating potential anti-anxiety effects.

 

2. Animal Feed Additives

Amentoflavone extract alleviates oxidative stress in livestock and poultry, thereby improving intestinal health.

 

3. Functional Foods & Additives

• Food Preservation: An addition of 0.3% can delay the oxidation of tea beverages by 70% and double the shelf life of dairy products.
• Dietary Supplements: A natural ingredient utilized for regulating blood glucose and blood lipids.

 

4. Cosmetic Ingredients

• Anti-Aging Serums: Stimulates collagen production.
• SPF Enhancement: Boosts SPF values ​​by 30%, serving as a substitute for chemical UV filters.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you would like to buy amentoflavone, please contact us: Email: info@fruiterco.com.

 

 

1. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/amentoflavone

2. https://muscleandbrawn.com/supplements/amentoflavone-what-it-is-how-it-works/

3. Aliyev AT, Ozcan-Sezer S, Akdemir A, Gurer-Orhan H (2021) In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone. Hum Exp Toxicol 40(9):1510–1518

4. Ambarwati NSS, Elya B, Malik A, Hanafi M, Awang MSN (2022) Isolation, identification, and antibacterial of amentoflavone from Garcinia latissima Miq. leaves. Int J Appl Pharm 14(Special Issue 3):67–73

5. Aminudin NI, Norazhar NA, Ahmad F (2021) Development of a HPLC method for quantification of amentoflavone in leaf extracts of three Calophyllum species. Malays J Chem 23(2):33–39

6. An J, Li Z, Dong Y, Ren J, Huo J (2016) Amentoflavone protects against psoriasis-like skin lesion through suppression of NF-κB-mediated inflammation and keratinocyte proliferation. Mol Cell Biochem 413(1):87–95

7. Bais S, Abrol N (2015) Review on chemistry and pharmacological potential of amentoflavone. Curr Resn Neurosci 6:16–22