What Are The Cosmetic Ingredients Similar To Kojic Acid?

 

Pure kojic acid powder is an organic compound with the chemical formula C6H6O4. It is mainly used as a whitening agent, food additive, preservative, preservative and color protectant. Its chemical properties and sources are:

 

• Molecular formula: C₆H₆O₄, a pyrone derivative, extracted through Aspergillus oryzae fermentation.
• Purity standard: cosmetic grade ≥99.5% (by HPLC), CAS number: 501-30-4.
• Stability: Best at pH 3.5-5.0, easily oxidized when exposed to light.

 

 

Benefits	Effect	Research data
Tyrosinase inhibition	Competitively binds copper ions (Ki=0.03μM)	8-week intervention reduced melanin index by 38%
Antioxidant	Scavenge hydroxyl radicals (ORAC value = 4,200 μmol TE/g)	UV-induced ROS reduction by 67%
Anti-glycation	Inhibit the production of AGEs (IC50=1.2mM)	Glycated hemoglobin decreased by 0.9%
Antibacterial	Destroys Staphylococcus aureus biofilms	Propionibacterium acnes killing rate 82%

 

 

1. Tyrosinase inhibitors

 

Raw material	Mechanism of action	Advantages	Limitation
Tetrahydrokojic acid	Hydrogenated kojic acid derivative, inhibits TRP-2	Photostability increased by 300%, irritation reduced by 80%	The cost is 4 times that of kojic acid
Arbutin	Hydrolysis produces hydroquinone, blocking melanin transport	Quick onset of effect	It is easy to decompose at high temperatures and may become blackened after long-term use
Azelaic acid	Inhibits abnormal melanocyte DNA synthesis	Effective for acne and can be used by pregnant women	Requires 20% concentration to be effective, may cause stinging

 

2. Antioxidant synergy

• Ellagic acid powder: Enhances cell defense through the Nrf2/ARE pathway, and when combined with kojic acid, the whitening effect is increased by 2.3 times.
• Phloretin: inhibits PAR-2 ​​receptors to reduce melanin transmission, and the transdermal absorption rate is 48% higher than kojic acid.
• Ergothioneine: mitochondria-targeted antioxidant, reversing photoaging pigmentation.

 

3. New biotechnology

• CRISPR-Cas9 edited yeast extract: Targeted silencing of the TYR gene, with a sustained inhibition efficiency of 95% for 48 hours.
• Marine psychrolysin: breaks down mature melanin granules.
• Whitening peptide (oligopeptide 68): simulates α-MSH antagonist and blocks MC1R signaling.

 

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you want to buy kojic acid powder, you can contact us: Email: info@fruiterco.com.

 

 

1. https://gethealthyskin.com/ingredients/kojic-acid

2. https://www.health.com/kojic-acid-soap-8357867

3. https://pubmed.ncbi.nlm.nih.gov/35960194/

4. https://www.sakhiyaskinclinic.com/skin-whitening-treatment-cost/

5. https://pubmed.ncbi.nlm.nih.gov/39195475/

6. https://pubmed.ncbi.nlm.nih.gov/35760760/

7. https://pubmed.ncbi.nlm.nih.gov/22579419/

8. https://pubmed.ncbi.nlm.nih.gov/27356545/