What are The Uses of Dihydromyricetin and are There Any Disadvantages?

 

Dihydromyricetin powder is an extract from the grape plant amelopsis grossedentata. It is the main active component of flavonoids in amelopsis grossedentata. These substances have many unique effects such as free radical scavenging, antioxidant, anti-thrombosis, anti-tumor, and anti-inflammatory.

 

It has special effects in reducing blood lipids and blood sugar levels, increasing SOD activity, and protecting the liver.

 

 

1. Antibacterial
DHM powder has obvious inhibitory effects on various bacteria, including cocci, bacilli, Gram-positive bacteria and Gram-negative bacteria, and also has a certain inhibitory effect on yeasts and molds.

 

2. Antioxidant
Dihydromyricetin can scavenge free radicals that cause cell aging, enhance antioxidant enzyme activity, reduce the production of MDA, and protect cellular DNA from oxidative damage.

 

 

3. Anti-tumor
Dihydromyricetin exerts anti-tumor effects by inhibiting the proliferation of liver cancer cells, breast cancer cells, ovarian cancer cells, prostate cancer cells, bladder cancer cells and osteosarcoma cells.

 

4. Neuroprotection
Dihydromyricetin extract can not only serve as a functional regulatory molecule for inhibitory neurotransmitter receptors, but also directly participate in the electrical signal transmission process at synapses in the brain.

 

It can also regulate nerve function by upregulating the expression of neurotrophic factors, indirectly repair damaged or aging nerve function by affecting apoptosis and autophagy pathways, and improve a variety of neuropsychiatric diseases.

 

Mainly including Alzheimer's disease, alcoholism, depression, anxiety and epileptic behavior, alleviating the autophagy process of damaged hippocampal neurons, improving brain function, etc.

 

 

Although dihydromyricetin is good, its bioavailability is very low!

 

1. Low solubility
The solubility of dihydromyricetin in water is only 0.7mg/mL.

 

2. Low stability in intestinal environment
Dihydromyricetin is stable under acidic conditions (pH 3-6), but easily decomposes under alkaline conditions. Studies have found that under pH 8.0 and 9.0 conditions, the retention of dihydromyricetin is only 25% and 5% respectively.

 

The small intestinal fluid is a weakly alkaline environment, so dhm extract is unstable and easily decomposes in the intestinal fluid environment.

 

3. Poor bioavailability
The oral bioavailability of dihydromyricetin is poor, only 4.02%.

 

 

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