what is Cycloastragenol Used For?

 

Cycloastragenol powder, also known as isoquercetin, is a flavonoid found in plants. It is made from quercetin combined with a glucose molecule. Cycloastragenol has a variety of biological activities and has certain application value in the fields of medicine and health care.

 

Cycloastragenol mainly exists in the following plants:

 

Astragalus membranaceus: Astragalus is a traditional Chinese medicinal material, and cycloastragalus is one of its main active ingredients.

Apple (Malus domestica): There is a certain amount of cycloastragenol, especially in the skin of the apple.

Onions (Allium cepa): Cycloastragenol is also present in the flavonoids found in onions.

Other plants: such as tea, cherries, blueberries, etc., may also contain cycloastragalin.

 

 

Analysis	Specification	Result	Test method
Physical Description
Appearance	Brown powder	Complies	Visual
Odor	Characteristic	Characteristic	Organoleptic
Chemical Tests
Identity	TLC	Complies	TLC
	HPLC	Complies	HPLC
Cycloastragenol	10.0% Min	10.62%	HPLC-RID
Loss on drying	5.0% Max	4.3%	USP40-NF35<731>
Residue on Ignition	5.0% Max	2.47%	USP40-NF35<561>
Heavy metals
Arsenic(MDL0.05)	1.5ppm Max	0.4ppm	ICP-MS
Lead(MDL0.02)	5.0ppm Max	0.2ppm	ICP-MS
Cadmium(MDL0.02)	0.3ppm Max	ND	ICP-MS
Mercury(MDL0.005)	0.1ppm Max	ND	ICP-MS
Microbiology Control
Total plate count	10,000cfu/g Max	400cfu/g	USP40-NF35<2021>
Yeast & Mold	100cfu/g Max	20cfu/g	USP40-NF35<2021>
E. Coli	Negative	Absent	USP40-NF35<2022>
Salmonella	Negative	Absent	USP40-NF35<2022>
Conclusion	Complies with the standards.
General Status	Non-GMO, Non-irradiation, ISO & Kosher Certificated.
Packing and Storage
Packing: Pack in paper-carton and two plastic-bags inside.
Shelf life: 2 year when properly stored.
Storage: Store in a well-closed place with constant low temperature and no direct sun light.

 

 

1. Antioxidant
Astragalus extract cycloastragenol has strong antioxidant capacity and helps eliminate free radicals in the body. 

 

The accumulation of DNA damage and telomere attrition can lead to an increase in senescent cells in tissues and organs, leading to the degradation of cell function and thus triggering a series of diseases related to cellular aging.

 

2. Anti-inflammatory
It can reduce symptoms caused by inflammation and has a certain anti-inflammatory effect.

 

3. Cardiovascular health
May help protect the cardiovascular system by improving blood vessel function and lowering blood pressure and cholesterol levels. 

 

In cardiovascular system diseases during treatment, astragalus cycloastragenol has been found to have preventive and therapeutic effects on heart failure, myocardial fibrosis, myocardial infarction, etc.

 

 

4. Immunomodulation
May help enhance immune system function.

 

5. Complications of diabetes
Refractory wound healing is a complication of diabetes. The wound healing process involves inflammatory responses, coagulation, epithelial regeneration, and neovascularization.

 

Epidermal stem cell (EpSC) formation and wound closure are considered important components of wound healing, and telomere dysfunction can lead to reduced EpSC proliferation and migration, which delays wound healing.

 

 

6. Anti-allergic
Studies have found that cycloastragenol extract exhibits certain anti-allergic effects.

 

7. Antidepressants
It induces TERT expression by activating the CREB signaling pathway in neuronal cells, exerts telomerase activation function, promotes cell survival and regulates TERT and bcl2 gene expression in the central nervous system, suggesting that CAG has a potential therapeutic effect on depression.

 

8. Enhance immunity
Study finds that increasing cycloastragalin increases telomeres in T lymphocytes enzyme activity, thereby enhancing the antiviral ability of cells, improved immunity of subjects.

 

 

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