7 8 DHF Dihydroxyflavone

 

7 8 DHF dihydroxyflavone is a natural flavonoid compound with significant biological activity, especially known for mimicking the function of brain-derived neurotrophic factor(BDNF).

 

7,8-DHF is mainly found in the following natural plants:

 

• Fruits and vegetables: such as citrus peels, apples, grapes, onions, etc.
• Medicinal plants: such as traditional Chinese medicines such as Ginkgo biloba and Scutellaria baicalensis.
• Artificial synthesis: The laboratory can obtain high-purity 7 8 DHF through chemical synthesis for research and pharmaceutical development.

 

 

Product	7,8-Dihydroxyflavone	CAS No.	38183-03-8
Quantity	5kg	Man.date	2021-09-28
Test standard	In-house quality standard	Expiry date	2years
Items	Specifications		Results
Appearance	yellow powder		Conforms
Assay(HPLC)	≥99.0%		99.3%
Loss on Drying	≤1.0%		0.25%
Conclusion：The product meets In-house specifications.

 

 

1. Neuroprotection and cognitive enhancement

• Activate the BDNF pathway: 7 8 DHF dihydroxyflavone is a highly selective agonist of the BDNF receptor TrkB, which can promote neuronal growth, synaptic plasticity, and improve learning and memory.
• Anti-neurodegenerative diseases: Studies have shown that it has potential therapeutic effects on Alzheimer's disease, Parkinson's disease, etc.

 

2. Antioxidant and anti-inflammatory
It can scavenge free radicals and reduce oxidative stress damage. It can also inhibit inflammatory factors and relieve chronic inflammation.

 

3. Metabolic regulation
7 8 DHF dihydroxyflavone may improve insulin sensitivity and assist in diabetes management. Regulate lipid metabolism and reduce the risk of cardiovascular disease.

 

4. Antidepressant and anti-anxiety
It mainly relieves depressive-like behaviors through the BDNF mechanism, and the effect is similar to some antidepressants.

 

 

1. Dose-dependent toxicity: high doses may cause elevated liver enzymes or gastrointestinal discomfort.

 

2. Drug interactions: combined use with anticoagulants may increase the risk of bleeding.

 

3. Long-term safety is unknown: current studies are mostly based on animal models, and the safety of long-term use in humans needs further verification.

 

 

1. Medical field

• Neurological disease treatment: Develop drugs as BDNF replacement therapy for neurodegenerative diseases or brain damage repair.
• Mental health: auxiliary ingredients of antidepressant and anti-anxiety drugs.

 

2. Health products and functional foods

7 8 DHF dihydroxyflavone is added to supplements for improving cognition or anti-aging.

 

3. Cosmetics
Antioxidant properties can be used in anti-aging skin care products.

 

 

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