Can Nattokinase Lower Blood Pressure?

May 20, 2025

What is Nattokinase?

 

Natto nattokinase is a serine protease produced by fermenting soybeans with Bacillus subtilis. It can directly degrade fibrin and has a strong ability to decompose blood clots. Therefore, it is an ingredient in many health products that lower blood pressure. Its characteristics include:

 

  • Small molecular weight: about 27.7 kDa, easily absorbed by the intestine.
  • Poor heat resistance: activity significantly reduced above 60°C.

 

Source:

 

1. Natural source: traditional Japanese natto.

 

2. Industrial production: extracted from soybeans fermented by Bacillus subtilis, or synthesized by genetic engineering recombinant technology.

 

3. Product form: capsules, tablets, powder (need to be stored at low temperature to maintain activity).

 

natto powder benefits:

 

1. Protect cardiovascular health

  • Dissolve blood clots: prevent and assist in the treatment of atherosclerosis, cerebral infarction, and myocardial infarction.
  • Lower blood pressure: inhibit angiotensin-converting enzyme, dilate blood vessels, suitable for patients with hypertension.
  • Improve blood flow: reduce blood viscosity and reduce microcirculatory disorders.

 

2. Anti-inflammatory and antioxidant
Nattokinase extract can reduce inflammatory markers such as C-reactive protein (CRP), potentially reducing the risk of chronic diseases. It can also scavenge free radicals and delay the aging of vascular endothelial cells.

 

3. Neuroprotection
Improve cerebral blood flow and assist in the prevention of Alzheimer's disease.

 

4. speed up blood circulation

Relieve venous reflux disorders such as varicose veins and hemorrhoids.

 

application:

 

Application areas Specific applications
Health food Dietary supplements for preventing blood clots and regulating blood pressure
Clinical assistance Prevent cardiovascular and cerebrovascular diseases
Functional food Add to natto and beverages to enhance health properties.
Scientific research purposes Experimental tools for studying the mechanisms of thrombotic diseases.

 

Natural nattokinase is a natural and highly effective fibrinolytic ingredient, suitable for long-term health care for the elderly and those at high risk of cardiovascular disease.

 

side effects of taking nattokinase:

 

1. Common risks:

  • Bleeding tendency: Combination with anticoagulants may increase the risk of bleeding.
  • Gastrointestinal discomfort: A small number of people experience abdominal distension and diarrhea.

 

2. Contraindications:
Pre- and post-operative, severe liver and kidney dysfunction, pregnant women and lactating women are prohibited from using.

 

3. Dosage control:
2000-4000 FU is recommended daily, and excessive dosage may cause hypotension.

 

Comparison with other thrombolytic agents:

 

Product Benefits limitation
Nattokinase Oral administration is effective and has a long-lasting effect Ineffective for acute thrombosis, long-term use is required
lumbrokinase Good effect on old thrombosis May cause allergic reactions
Urokinase (injection) Rapid thrombolysis for emergency treatment Requires intravenous administration, high risk of bleeding

 

Contact Us:

 

Fruiterco is an export company that mainly produces plant extracts, health product raw materials, and cosmetic raw materials. The company has a 20+ professional service after-sales team.

 

Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you want to buy nattokinase, you can contact us: Email: info@fruiterco.com.

 

References:

 

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC5372539/

2. https://www.verywellhealth.com/what-is-nattokinase-89831

3. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/nattokinase

4. https://www.webmd.com/diet/health-benefits-nattokinase

5. https://pmc.ncbi.nlm.nih.gov/articles/PMC9550699/

6. https://j-nattokinase.org/en/jnka_nattou_01.html

7. https://www.lifeextension.com/wellness/supplements/nattokinase-benefits

8. https://www.drugs.com/npp/nattokinase.html

9. https://draxe.com/nutrition/natto/

10. https://www.jfda-online.com/journal/vol20/iss3/1/

 

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