Can People With High Blood Pressure Use Deglycyrrhizinated Licorice Extract?
Jan 19, 2026
what is Deglycyrrhizinated Licorice Extract?
Deglycyrrhizinated licorice extract (DGL) is a specially processed licorice extract that removes glycyrrhizin while retaining other active ingredients.
benefits:
1. Regulates the digestive system
It can relieve chronic indigestion, heartburn, and gastric and duodenal ulcers by promoting mucus secretion and repairing the gastric mucosa.
2. Accelerates wound healing
DGL deglycyrrhizinated licorice root extract reduces pain from oral ulcers and accelerates healing.
3. High safety profile
Because it does not contain glycyrrhizic acid, there is no risk of raising blood pressure or causing sodium and water retention, making it suitable for people with high blood pressure.
4. Antioxidant
It retains flavonoids, which have anti-inflammatory and antioxidant effects.
what is deglycyrrhizinated licorice used for?
1. Dietary Supplements
The powder can be made into chewable tablets, capsules, etc., for daily digestive health maintenance.
2. Pharmaceutical Excipients
As a gastric mucosa protectant, DGL extract can assist in the treatment of peptic ulcers.
3. Oral Care
Mouthwashes or lozenges containing DGL can improve oral inflammation.
Deglycyrrhizinated Licorice Extract vs. licorice extract:
| Contrast | Deglycyrrhizinated Licorice Extract | Licorice Extract Powder |
| Active ingredients | Glycyrrhizic acid ≤3%, retaining flavonoids | Glycyrrhizic acid ≥65% |
| Security | No risk of raising blood pressure, suitable for a wide range of people | Long-term use may lead to high blood pressure and edema. |
| Benefits | Digestive tract mucosal repair and ulcer treatment | Sweetener, anti-inflammatory, cough suppressant |
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references:
1. Chandler R.F. Licorice, more than just a flavour. Can Pharm J. 1985;118:421–424.
2. Tamir S., Eizenberg M., Somjen D., et al. Estrogen-like activity of glabrene and other constituents isolated from licorice root. J Steroid Biochem Mol Biol. 2001;78:291–298.
3. Farese R.V., Jr., Biglieri E.G., Shackleton C.H., et al. Licorice-induced hypermineralocorticoidism. N Engl J Med. 1991;325:1223–1227.
4.https://pmc.ncbi.nlm.nih.gov/articles/PMC10261761/#:~:text=These%20results%20suggest%20that%20dipeptides,a%20novel%20functional%20food%20ingredient.
5. Wang Z.Y., Nixon D.W. Licorice and cancer. Nutr Cancer. 2001;39:1–11.
6. Takahashi T., Takasuka N., Iigo M., et al. Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci. 2004;95:448–453.
7. Licorice Root." National Center for Complementary and Integrative Health. August 2020.
8. https://www.webmd.com/vitamins/ai/ingredientmono-881/licorice#dosing
9. https://www.nccih.nih.gov/health/licorice-root
