What Are The Applications Of Palmitoyl Tetrapeptide 7 In Skin Care?
Dec 05, 2025
what is Palmitoyl Tetrapeptide 7 Powder?
Palmitoyl tetrapeptide 7 powder is a synthetic peptide cosmetic ingredient composed of a palmitoyl group and four amino acids (glycine-glutamine-proline-arginine, with the sequence Pal-Gly-Gln-Pro-Arg). It is primarily used in skincare products for anti-aging, repair, and firming functions.
palmitoyl tetrapeptide 7 benefits:
1. Anti-inflammatory
It can inhibit the synthesis of pro-inflammatory factors, reducing the damage to collagen caused by chronic inflammation.
2. Anti-glycation
It delays the formation of advanced glycation end products (AGEs), protects collagen fiber structure, and prevents skin hardening.
3. Promotes collagen synthesis
It can stimulate the production of dermal collagen (type IV and VII) and laminin, enhancing skin elasticity.
4. Barrier repair
It repairs UV damage, improves uneven skin tone, and strengthens the epidermal barrier function.
5. Anti-aging
It can be used in combination with palmitoyl oligopeptides or palmitoyl tripeptide-1 to increase collagen density and enhance the firming effect.
Applications:
1. Anti-aging Skincare Products
- Serum
- Face cream
- Eye cream
2. Repair and Post-treatment Care
- Repair after laser treatment and chemical peels
- Used in conjunction with microneedling or radiofrequency devices
3. Anti-glycation Products
It can be combined with ingredients such as carnosine and pterostilbene to improve dullness and loss of elasticity caused by glycation.
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References:
1. El Hadmed, H & Castillo, R, 2016. 'Cosmeceuticals: peptides, proteins, and growth factors', Journal of Cosmetic Dermatology, vol. 15, is. 4, pp 514-519.
2. Schagen, S, 2017. 'Topical Peptide Treatments with Effective Anti-Aging Results', Cosmetics, vol. 4, is. 2.Apone, F, Barbulova, A & Colucci, M, 2019. 'Plant and Micoralgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics', Frontiers in Plant Science, vol. 10.
3. Johnson, w et al. 2018. 'Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics', International Journal of Toxicology.
4. Trookman, N, Rizer, R, Ford, R, Ho, E & Gotz, V, 2009. 'Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles', Journal of Clinical and Aesthetic Dermatology', vol. 2, is. 3, pp. 38-43.
5. https://www.specialchem.com/cosmetics/inci-ingredients/palmitoyl-tetrapeptide-7
6. https://www.activepeptide.com/product/palmitoyl-tetrapeptide-7/
