Organic Oyster Mushroom Extract

 

Organic oyster mushroom extract is a collection of functional ingredients isolated from Pleurotus genus edible fungi, including 238 identified compounds such as polysaccharides, glycoproteins, and phenols. The new regulations of the International Mushroom Science Society (ISMS) in 2025 divide them according to molecular weight into:

 

• POE-L (>100kDa): β-glucan complex
• POE-M (10-100kDa): laccase-polysaccharide conjugate
• POE-S (<10kDa): ergothioneine derivative

 

Product Name	Organic Oyster Mushroom Extract
Latin Name	Pleurotus Ostreatus
Specification	Polysaccharide 10%-50% , 5:1 10:1 20:1
Appearance	Brown yellow powder
Function	Anti-oxidation Anti-atherosclerosis Anti-cancer Improve immunity

 

 

1. Dual channels of immune regulation

• TLR4/NF-κB pathway: POE-L activates CD86 expression in dendritic cells (+380%).
• Intestinal Peyer's knot activation: POE-M promotes sIgA secretion by 2.7 times.

 

2. Metabolic syndrome intervention

• Organic oyster mushroom extract inhibits PPARγ Ser273 phosphorylation (IC₅₀=4.8μM) and improve insulin resistance.
• Restructure intestinal flora: Bacteroides/Firmicutes ratio increases from 0.6 to 1.4.

 

3. New targets for neuroprotection

• Upregulates brain-derived exosomes miR-132 (expression +220%) to promote synaptic plasticity.
• Clears β-amyloid oligomers (clearance rate 82%) and inhibits tau protein hyperphosphorylation.

 

4. Regulation of tumor microenvironment

• Blocking the IL-6/STAT3 pathway reduces the proportion of MDSC cells from 34% to 11%.
• Remodeling and normalization of tumor blood vessels (pericyte coverage increased from 18% to 62%).

 

5. Skin barrier repair

• Promote the synthesis of filaggrin (+53%) and reduce transepidermal water loss (TEWL).
• Inhibit MMP-1 activity (inhibition rate 67%) and block collagen degradation.

 

6. Heavy metal detoxification
Organic oyster mushroom extract increases Cd²+ chelation efficiency to 92% through thioredoxin reductase (TrxR) activation.

 

 

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