Can Naringenin Anti-cancer?

 

Naringenin powder is also called naringenin and citrusin. It is an aglycone obtained by hydrolyzing a molecule of glucose and rhamnose from naringin.

 

Naringenin is a dihydroflavone compound that appears as a white to yellow crystalline fine powder. It is soluble in ethanol, ether and benzene, and almost insoluble in water.

 

Naringenin has a wide range of sources and can be extracted from citrus fruits, such as grapefruit, lemon and orange, as well as grapes, tomatoes, sour cherries, cattails, citrus aurantium and other plants. Among them, the content of naringenin in grapefruit peels Highest.

 

Naringenin has a variety of pharmacological activities, including antioxidant, anti-tumor, anti-viral, anti-bacterial, anti-inflammatory, hypolipidemic, antitussive, anti-arrhythmic, anti-arteriosclerosis, etc., and is widely used in the fields of medicine, food, health products, cosmetics and other fields. The application prospects are broad.

 

In the medical field, naringenin has been used in a variety of pharmaceutical preparations to treat diabetes, hypertension, osteoporosis, cardiovascular disease, cancer, obesity and other diseases.

 

 

1. Inhibit pancreatic lipase
Pancreatic lipase is a key enzyme for digesting dietary fat. Inhibiting pancreatic lipase activity can reduce the digestion and absorption of dietary triglycerides. Studies have found that naringenin extract can significantly reduce the levels of triglycerides, cholesterol and free fatty acids in obese rats.

 

2. Antioxidant
Studies have shown that naringenin is a moderately absorbed biological macromolecule that can penetrate Caco-2 cells, mainly mediated by the active transport pathway involved in P-glycoprotein. At the same time, naringenin pretreatment can significantly improve the viability of Caco-2 cells induced by H2O2.

 

3. Regulate estrogen
Based on the estrogen-like effects of naringenin, naringenin powder can be used for estrogen replacement therapy in postmenopausal women to avoid serious adverse reactions caused by long-term use of estrogen.

 

4. Improve symptoms of hyperlipidemia
Animal studies have shown that naringenin reduces the gene expression of gluconeogenesis-related enzymes, significantly reduces blood sugar and plasma insulin levels in mice induced by high fat, improves glucose tolerance symptoms in peripheral tissues, and increases glucose uptake and absorption in skeletal muscles. Utilized, naringenin can significantly improve the symptoms of hyperlipidemia.

 

 

5. Anti-inflammatory activity
Naringenin powder has an activity similar to that of non-steroidal anti-inflammatory drugs. It reduces the synthesis of prostaglandin PGE2 by inhibiting cyclooxygenase COX, and plays an antipyretic, analgesic and inflammation-relieving role.

 

6. Regulate immune cells
Reactive oxygen species (ROS) are mainly composed of cells NOX family members are produced in intracellular mitochondria and cytoplasmic membranes, which are sources of intracellular oxidative stress. Flavonoids regulate the function of immune cells by regulating the production of ROS in immune cells.

 

7. Antibacterial
It has strong antibacterial effects against Staphylococcus aureus, large intestine, dysentery and typhoid bacilli. Naringenin powder also has an effect on fungi and is not toxic to humans and livestock.

 

8. Hypolipidemic effect
Animal studies have found that at a certain dose, naringenin can significantly reduce serum TC, TG, and LDL-C, and relatively increase serum HDL-C, indicating that naringenin has a blood-lipid-lowering effect in mice.

 

 

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