What Is The Difference Between Betulin And Betulinic Acid?
Dec 02, 2025
what is Betulin Powder?
Betulin powder is a natural pentacyclic triterpenoid compound widely found in plants such as birch, possessing various biological activities and applications.
- Its main sources: Birch bark, the core source, containing up to 30% of its dry weight.
- Other plants: Roots of Saussurea costus (Asteraceae), roots of Myrtaceae, etc.
Supercritical CO₂ extraction yields a purity of up to 99% as determined by HPLC.
betulin benefits:
1. Anti-tumor effects
It can induce apoptosis in cancer cells and inhibit their proliferation, showing significant effects, especially against cervical cancer, neuroblastoma, and ovarian cancer.
2. Auxiliary regulation of blood lipids
Animal experiments show that betulin may help lower cholesterol and triglyceride levels by inhibiting cholesterol synthesis-related enzymes, thus having a certain auxiliary regulatory effect on people with hyperlipidemia.
3. Anti-inflammatory
Birch bark extract betulin can inhibit pro-inflammatory factors, reduce inflammatory responses, and may have an auxiliary effect in improving certain inflammatory diseases.
4. Antiviral
It has an inhibitory effect on HIV, interfering with the viral maturation process.
5. Hair care
It reduces hair protein breakdown, promotes hair growth, and improves shine.
6. Liver protection
It alleviates alcoholic liver damage and enhances antioxidant capacity.
7. Skin health
Betulin is often used in skin care products and helps improve acne, promote wound healing, and enhance the skin barrier function.
betulin uses:
1. Pharmaceutical Industry
2. Cosmetics
Added to hair care products and anti-inflammatory skin care products.
3. Food Additive
Used as a functional ingredient in health foods for anti-oxidation and metabolism regulation.
What is the difference between betulinic acid and Betulin?
| Contrast | Betulin | Betulinic acid powder |
| Molecular formula | C₃₀H₅₀O₂ | C₃₀H₄₈O₃ |
| Functional Group | -OH | -COOH |
| Appearance | White crystals powder | Light yellow crystals powder |
| Melting point | 256-258℃ | 295-298℃ |
| Solubility | Soluble in ethanol and chloroform; slightly soluble in cold water | Slightly soluble in water, readily soluble in pyridine and tetrahydrofuran |
| Uses | Pharmaceutical intermediates,hair care products,food additives | Anti-cancer, anti-inflammatory, neuroprotective |
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References:
1. https://pmc.ncbi.nlm.nih.gov/articles/PMC6259842/
2. https://pubmed.ncbi.nlm.nih.gov/37509141/#:~:text=Betulin%20is%20a%20natural%20triterpene%20that%20has,*%20Diabetes%20*%20Oxidative%20stress%20*%20Inflammation
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC10377123/
4. https://www.herbs2000.com/h_menu/betulin.htm
5. https://innomost.com/what-is-betuinno-betulin
6. Tolstikov G.A., Flekhter O.B., Shul'ts E.E., Baltina L.A., Tolstikov A.G. Betulin and its derivatives. Chemistry and biological activity. Khim. Interes. Ust. Razv. 2005;13:1–30.
7. Schulze H., Pieroh K. Zur Kenntnis des Betulins. Chem. Ber. 1922;55:2322–2346.
8. Davy G.S., Halsall T.G., Jones E.R.H., Meakins G.D. The chemistry of the triterpenes. Part X. The structures of some isomerisation products from betulin and betulinic acid. J. Chem. Soc. 1951:2702–2705.






