What Are The Benefits Of Tripterygium Wilfordii Extract?

What is Tripterygium wilfordii?

Tripterygium wilfordii extract comes from Tripterygium wilfordii, a perennial vine of the Celastraceae family, which is widely distributed in the Yangtze River Basin and southern mountainous areas of my country. Its roots, stems, and leaves all contain active ingredients, but the root bark is mainly used in traditional medicine.

Traditional Chinese medicine records that it has the effects of "dispelling wind and dampness, activating blood circulation and unblocking meridians", but due to its significant toxicity, it needs to be processed before being used as medicine.

Preparation technology of Tripterygium wilfordii extract:

1. Raw material pretreatment
(1) Collect 2-3 year old Tripterygium wilfordii roots, wash and slice or crush, and reduce toxic precursors by ethanol soaking or steam inactivation.

2. Extraction of active ingredients

Solvent extraction: commonly use ethanol-water mixed solvent (60-80% concentration), through reflux or ultrasound-assisted extraction, focus on enriching diterpenes (such as tripterygium wilfordii) and alkaloids.

Supercritical CO₂ extraction: selectively extract low polarity components (such as tripterygium wilfordii) under high pressure and low temperature conditions to avoid high temperature damage to heat-sensitive substances.

Macroporous resin purification: remove impurities such as pigments and polysaccharides, and improve the purity of target components (such as glycosides).

3. Quality control
HPLC is used to detect key components (such as the content of tripterygium wilfordii must be controlled at 0.01-0.1%), which meets the standards of the "Chinese Pharmacopoeia".

Core active ingredients and functions:

Ingredient Category	Active ingredients	Main functions
Diterpenoids	Triptolide	Inhibit NF-κB pathway, anti-inflammatory and anti-tumor
Triterpenoids	Celastrol	Activate HSP90 and improve metabolic syndrome
Alkaloids	Wilfordine	Regulate T lymphocyte activity for autoimmune diseases
Glycosides and others	Tripterygium glycosides	Reduce inflammatory factors such as IL-2 and TNF-α to treat rheumatoid arthritis

tripterygium wilfordii root extract uses:

1. Anti-inflammatory and immunomodulatory
It can achieve anti-inflammatory and immunomodulatory effects by inhibiting T cell proliferation and B cell antibody secretion, reducing rheumatoid factor and anti-CCP antibody levels.

2. Anti-tumor
Triptolide can reverse the resistance of tumor cells to cisplatin, and improve the efficacy of chemotherapy by 20-30% in ovarian cancer and lung cancer.

3. Metabolic disease intervention
Celastrol can activate the AMPK pathway and promote fat decomposition. In animal experiments, it can reduce the weight of obese mice by more than 15%.

4. Organ protection potential

Lignans inhibit TGF-β1 signaling and delay liver and kidney fibrosis.

5. Agricultural and ecological applications

As a plant-based pesticide, 0.5% tripterygium wilfordii root extract has a comparable control effect on aphids as chemical pesticides, without any residual risk.

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Our products are sold to North America, Europe, Australia, South America and Asia. Our products have passed quality inspection and also support customer re-inspection. If you want to buy tripterygium wilfordii extract, you can contact us: Email: info@fruiterco.com.